Grafted chitosan nanogel with 3,4-methylenedioxycinnamic acid: synthesis, characterization and application in the encapsulation of monoterpenes with antifungal properties

被引：2

作者：

Ladeira, Giordane ^{[1
]}

de Carvalho, Stephanne Yonara Barbosa ^{[1
]}

Rocha, Natalia Aparecida Pinto ^{[1
]}

Soares, Isabela Carla ^{[1
]}

Cipriano, Daniel Fernandes ^{[2
]}

de Freitas, Jair Carlos Checon ^{[2
]}

Guimaraes, Luiz Gustavo de L. ^{[1
,3
]}

机构：

[1] Univ Fed Sao Joao del Rei, Nat Sci Dept, Sao Joao Del Rei, MG, Brazil

[2] Univ Fed Espirito Santo, Dept Phys, Lab Carbon & Ceram Mat, Vitoria, ES, Brazil

[3] Univ Fed Sao Joao del Rei, Nat Sci Dept, Campus Dom Bosco, BR-36301160 Sao Joao Del Rei, MG, Brazil

来源：

INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 06期

关键词：

Carvacrol; chitosan; dermatophytosis; Microsporum canis; nanogel; thymol; ENHANCED ANTIMICROBIAL ACTIVITY; ESSENTIAL OILS; CINNAMIC ACID; FERULIC ACID; DERIVATIVES; ANTIBACTERIAL; NANOPARTICLES; EXTRACT; THYMOL; CHITIN;

D O I：

10.1080/00914037.2022.2163643

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Herein, a novel grafted chitosan nanogel with 3,4-methylenedioxycinnamic acid was carried out aiming at the encapsulation of the monoterpenes carvacrol and thymol, with the purpose of developing a material that can be used in the control of the fungus Microsporum canis. The nanogel encapsulation efficiency showed an encapsulation capacity of 12.9% carvacrol and 13.3% thymol. When in an aqueous medium the nanogel with the respective encapsulated monoterpene oils was able to form stable nanoparticles. The nanogels chitosan-g-3,4-methylenedioxycinnamic acid-carvacrol and chitosan-g-3,4-methylenedioxycinnamic acid-thymol showed antifungal potential against the fungus Microsporum canis, being able to inhibit mycelial growth by 100.00 and 93.13%, respectively.

引用

页码：405 / 416

页数：12