Grafted chitosan nanogel with 3,4-methylenedioxycinnamic acid: synthesis, characterization and application in the encapsulation of monoterpenes with antifungal properties

被引：2
作者：
Ladeira, Giordane [1 ]
de Carvalho, Stephanne Yonara Barbosa [1 ]
Rocha, Natalia Aparecida Pinto [1 ]
Soares, Isabela Carla [1 ]
Cipriano, Daniel Fernandes [2 ]
de Freitas, Jair Carlos Checon [2 ]
Guimaraes, Luiz Gustavo de L. [1 ,3 ]
机构：
[1] Univ Fed Sao Joao del Rei, Nat Sci Dept, Sao Joao Del Rei, MG, Brazil
[2] Univ Fed Espirito Santo, Dept Phys, Lab Carbon & Ceram Mat, Vitoria, ES, Brazil
[3] Univ Fed Sao Joao del Rei, Nat Sci Dept, Campus Dom Bosco, BR-36301160 Sao Joao Del Rei, MG, Brazil
来源：
INTERNATIONAL JOURNAL OF POLYMERIC MATERIALS AND POLYMERIC BIOMATERIALS | 2024年 / 73卷 / 06期
关键词：
Carvacrol; chitosan; dermatophytosis; Microsporum canis; nanogel; thymol; ENHANCED ANTIMICROBIAL ACTIVITY; ESSENTIAL OILS; CINNAMIC ACID; FERULIC ACID; DERIVATIVES; ANTIBACTERIAL; NANOPARTICLES; EXTRACT; THYMOL; CHITIN;
D O I：
10.1080/00914037.2022.2163643
中图分类号：
TB3 [工程材料学]; R318.08 [生物材料学];
学科分类号：
0805 ; 080501 ; 080502 ;
摘要：
Herein, a novel grafted chitosan nanogel with 3,4-methylenedioxycinnamic acid was carried out aiming at the encapsulation of the monoterpenes carvacrol and thymol, with the purpose of developing a material that can be used in the control of the fungus Microsporum canis. The nanogel encapsulation efficiency showed an encapsulation capacity of 12.9% carvacrol and 13.3% thymol. When in an aqueous medium the nanogel with the respective encapsulated monoterpene oils was able to form stable nanoparticles. The nanogels chitosan-g-3,4-methylenedioxycinnamic acid-carvacrol and chitosan-g-3,4-methylenedioxycinnamic acid-thymol showed antifungal potential against the fungus Microsporum canis, being able to inhibit mycelial growth by 100.00 and 93.13%, respectively.
引用
收藏
页码：405 / 416
页数：12
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