Investigation of Three Morchella Species for Anticancer Activity Against Colon Cancer Cell Lines by UPLC-MS-Based Chemical Analysis

被引：7
作者：
Ul Haq, Faiz [1 ]
Imran, Muhammad [1 ]
Saleem, Sidrah [1 ]
Rafi, Ali [2 ]
Jamal, Muhsin [3 ]
机构：
[1] Univ Hlth Sci, Dept Microbiol, Lahore, Pakistan
[2] Univ Hlth Sci, Dept Pharmacol, Lahore, Pakistan
[3] Abdul Wali Khan Univ, Dept Microbiol, Garden Campus, Mardan, Pakistan
来源：
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2023年 / 195卷 / 01期
关键词：
Cancer; Cytotoxicity; Morchella; Mycology; Anticancer agents; Fungal compounds; ANTIMICROBIAL ACTIVITY; EDIBLE MUSHROOMS; MOREL MUSHROOM; GROWTH;
D O I：
10.1007/s12010-022-04131-z
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In search of new anticancer agents, natural products including fungal compounds had been used as potential anticancer agents. The aim of this study was to investigate the anticancer activity of Morchella extracts against colon cancer cell line and UPLC-DAD-MS/MS analysis for the identification of compounds. The cytotoxic activity of the three Morchella species was examined for their anti-carcinogenic properties against the colon cancer cell lines. Phytochemical analyses were performed to screen Morchella for the presence of anti-cancerous compounds. All the fungal extracts inhibited the viability of colon cancer cells in a dose-dependent manner. Major compounds identified in Morchella included amino acid, fatty acid, sterol, flavonoid, peptide, glutamic acid, alkaloid, terpenoid, cyclopyrrolones, and coumarin. Several new compounds were detected among all the three Morchella extracts. In conclusion, all the fungal extracts showed potential inhibition of colon cancer cells and actively arrested the cell viability. It was concluded that the identified bioactive compounds might be the main constituents contributing to the anticancer activity of Morchella against human colon cancer cell lines. Thus, Morchella extracts are a potential source of bioactive compounds with cytotoxicity and could potentially be used as functional food supplements. Due to the nature of impressive findings, this investigation should be undertaken further to allow the studies to explore and develop a potential cytotoxic agents against colon cancer.
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页码：486 / 504
页数：19
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