Copper-Catalyzed Fluoroamide-Directed Remote C(sp3)-H Bond Functionalization Through Intramolecular Hydrogen Atom Transfer

被引：6

作者：

Lv, Xin ^{[1
]}

Yang, Yuhao ^{[2
]}

Zhou, Liejin ^{[1
]}

Zeng, Xiaojun ^{[3
]}

机构：

[1] Zhejiang Normal Univ, Coll Chem & Mat Sci, Key Lab Minist Educ Adv Catalysis Mat, 688 Yinbing Rd, Jinhua 321004, Zhejiang, Peoples R China

[2] Univ Louisville, Dept Chem, Louisville, KY 40292 USA

[3] Nanchang Univ, Sch Chem & Chem Engn, Nanchang 330031, Jiangxi, Peoples R China

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2024年 / 27卷 / 13期

基金：

中国国家自然科学基金;

关键词：

Remote C(sp(3))-H functionalization; copper catalysis; fluoramide; radical reactions; hydrogen atom transfer; C-H BONDS; CYANATION; ALKYLATION; ARYLATION; IRON;

D O I：

10.1002/ejoc.202400027

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Direct C-H functionalization is an important strategy for the rapid synthesis of valuable organic molecules. Radical-involved remote C(sp(3))-H functionalization based on hydrogen atom transfer (HAT) becomes an important method enabling selective direct transformation of C(sp(3))-H bonds at specific distal position(s). In the recent years, copper-catalyzed fluoroamide-directed remote C(sp(3))-H bond functionalization through intramolecular HAT has served as a robust and elegant strategy for the assembly of a variety of functionalized (sulfon)amides and related derivatives. This review focuses on the recent advances in this area. These transformations proceed effectively with high selectivities and good functional group compatibility under mild conditions.

引用

页数：22

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