Induced-pluripotent stem cells and neuroproteomics as tools for studying neurodegeneration

被引：0

作者：

Brandao-Teles, Caroline ^{[1
]}

Zuccoli, Giuliana S. ^{[1
]}

Vrechi, Talita Aparecida de Moraes ^{[1
]}

Ramos-da-Silva, Livia ^{[1
]}

Santos, Aline Valeria Sousa ^{[1
]}

Crunfli, Fernanda ^{[1
]}

Martins-de-Souza, Daniel ^{[1
,2
,3
,4
,5
]}

机构：

[1] Univ Estadual Campinas, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, Campinas, Brazil

[2] Univ Estadual Campinas, Expt Med Res Cluster EMRC, BR-13083862 Campinas, SP, Brazil

[3] Conselho Nacl Desenvolvimento Cientif & Tecnol, Inst Nacl Biomarcadores Neuropsiquiatria, Sao Paulo, Brazil

[4] INCT Modelling Human Complex Dis 3D Platforms Mod, Sao Paulo, Brazil

[5] DOr Inst Res & Educ IDOR, Sao Paulo, Brazil

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2024年 / 52卷 / 01期

基金：

巴西圣保罗研究基金会;

关键词：

PARKINSONS-DISEASE; ALZHEIMER-DISEASE; TARGET IDENTIFICATION; APOLIPOPROTEIN-E; GENE; MUTATIONS; NEURONS; PROTEOMICS; PATHOLOGY; IPSC;

D O I：

10.1042/BST20230341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The investigation of neurodegenerative diseases advanced significantly with the advent of cell-reprogramming technology, leading to the creation of new models of human illness. These models, derived from induced pluripotent stem cells (iPSCs), facilitate the study of sporadic as well as hereditary diseases and provide a comprehensive understanding of the molecular mechanisms involved with neurodegeneration. Through proteomics, a quantitative tool capable of identifying thousands of proteins from small sample volumes, researchers have attempted to identify disease mechanisms by detecting differentially expressed proteins and proteoforms in disease models, biofluids, and postmortem brain tissue. The integration of these two technologies allows for the identification of novel pathological targets within the realm of neurodegenerative diseases. Here, we highlight studies from the past 5 years on the contributions of iPSCs within neuroproteomic investigations, which uncover the molecular mechanisms behind these illnesses.

引用

页码：163 / 176

页数：14

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