Small-vessel disease in the brain

被引：14

作者：

Singh, Amita ^{[1
]}

Bonnell, Gabriel ^{[1
]}

De Prey, Justin ^{[1
]}

Buchwald, Natalie ^{[1
]}

Eskander, Kyrillos ^{[1
]}

Kincaid, Keith J. ^{[1
]}

Wilson, Christina A. ^{[1
,2
]}

机构：

[1] Univ Florida, Dept Neurol, Gainesville, FL USA

[2] Univ Florida, Dept Neurol, 1149 Newell Dr,POB 100236, Gainesville, FL 32610 USA

来源：

AMERICAN HEART JOURNAL PLUS: CARDIOLOGY RESEARCH AND PRACTICE | 2023年 / 27卷

关键词：

Small-vessel disease; Brain; Ischemic stroke; Hemorrhage; Vascular dementia; CEREBRAL AMYLOID ANGIOPATHY; HEALTH-CARE PROFESSIONALS; CORONARY MICROVASCULAR DYSFUNCTION; ISCHEMIC-STROKE SUBTYPES; RISK-FACTORS; SECONDARY PREVENTION; LACUNAR STROKE; POOLED ANALYSIS; ASPIRIN USE; POPULATION;

D O I：

10.1016/j.ahjo.2023.100277

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cerebral small-vessels are generally located in the brain at branch points from major cerebral blood vessels and perfuse subcortical structures such as the white matter tracts, basal ganglia, thalamus, and pons. Cerebral smallvessel disease (CSVD) can lead to several different clinical manifestations including ischemic lacunar stroke, intracerebral hemorrhage, and vascular dementia. Risk factors for CSVD overlap with conventional vascular risk factors including hypertension, diabetes mellitus, and hypercholesterolemia, as well as genetic causes. As in cardiovascular disease, treatment of CSVD involves both primary and secondary prevention. Aspirin has not been established as a primary prevention strategy for CSVD among the general population; however, long-term antiplatelet therapy with aspirin alone continues to be the mainstay of secondary stroke prevention for noncardioembolic ischemic stroke and high-risk TIA.

引用

页数：10

共 91 条

[21] Spectrum of Transient Focal Neurological Episodes in Cerebral Amyloid Angiopathy Multicentre Magnetic Resonance Imaging Cohort Study and Meta-Analysis [J].