Synthesis and Phosphonylation of 6-Methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylic Acids Ethyl Esters

被引：2
|
作者：
Nosova, N. A. [1 ]
Skrylkova, A. S. [2 ]
Egorov, D. M. [2 ]
机构：
[1] St Petersburg State Chem Pharmaceut Univ, St Petersburg 197376, Russia
[2] Tech Univ, St Petersburg State Technol Inst, St Petersburg 190013, Russia
来源：
RUSSIAN JOURNAL OF GENERAL CHEMISTRY | 2023年 / 93卷 / 09期
关键词：
Biginelli reaction; phosphonylation; thiazolo[3,2-a]pyrimidine; 2-thio-1,2,3,4-tetrahydropyrimidine; BIOLOGICAL-ACTIVITY; DERIVATIVES;
D O I：
10.1134/S1070363223090062
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A new series of 6-methyl-4-aryl-2-thio-1,2,3,4-tetrahydropyrimidine-5-carboxylic acids ethyl esters was synthesized. The reaction of the obtained esters with dimethyl 2-chloroethynylphosphonate leads to the selective formation of new ethyl 3-(dimethoxyphosphoryl)-5-aryl-7-methyl-5H-thiazolo[3,2-a]pyrimidine-6-carboxylates.
引用
收藏
页码：2230 / 2236
页数：7
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