Research Reviews: Advances in methods for evaluating child and adolescent mental health interventions

被引:1
作者
Pickles, Andrew [1 ,2 ]
Edwards, Danielle [1 ]
Horvath, Levente [1 ]
Emsley, Richard [1 ]
机构
[1] Kings Coll London, Dept Biostat & Hlth Informat, London, England
[2] Kings Coll London, Dept Biostat & Hlth Informat, Denmark Hill, London SE5 8AF, England
关键词
Adaptive trial; sequential randomisation; SMART; TWIC; MAMS; MOST; RCT; instrumental variable; target trial emulation; TARGETED THERAPY; OUTCOMES; TRIAL;
D O I
10.1111/jcpp.13892
中图分类号
B844 [发展心理学(人类心理学)];
学科分类号
040202 ;
摘要
BackroundThe evidence base for interventions for child mental health and neurodevelopment is weak and the current capacity for rigorous evaluation limited. We describe some of the challenges that make this field particularly difficult and expensive for evaluation studies.MethodsWe describe and review the use of novel study designs and analysis methodology for their potential to improve this situation.ResultsWhile several novel designs appeared ill-suited to our field, systematic review found others that offered potential but had yet to be widely adopted, some not at all.ConclusionsWhile funding is inevitably a constraint, we argue that improvements in the evidence base of both current and new treatments will only be achieved by the adoption of a number of these new technologies and study designs, the consistent application of rigorous constructive but demanding standards, and the engagement of the public, patients, clinical and research services to build a design, recruitment, and analysis infrastructure.
引用
收藏
页码:1765 / 1775
页数:11
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