Direct C(sp2)-H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes

被引：8
作者：
Wang, Wenwen [1 ,2 ]
Zhu, Tonghao [1 ,2 ]
Wu, Jie [1 ,2 ,3 ,4 ]
机构：
[1] Taizhou Univ, Sch Pharmaceut & Chem Engn, 1139 Shifu Ave, Taizhou 318000, Peoples R China
[2] Taizhou Univ, Inst Adv Studies, 1139 Shifu Ave, Taizhou 318000, Peoples R China
[3] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[4] Henan Normal Univ, Sch Chem & Chem Engn, Xinxiang 453007, Peoples R China
来源：
ORGANIC CHEMISTRY FRONTIERS | 2023年 / 10卷 / 21期
基金：
中国国家自然科学基金;
关键词：
LIGHT-INDUCED HYDRODIFLUOROMETHYLATION; ALDOSE REDUCTASE INHIBITORS; POTENT; CHEMISTRY; FLUORINE; DESIGN; DERIVATIVES; ANTITUMOR; RECEPTOR; KETONES;
D O I：
10.1039/d3qo01247f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A photoredox-catalyzed direct C(sp(2))-H fluoroalkylation of quinoxalin-2(1H)-ones with (fluoroalkyl)triphenylphosphonium salts and alkenes is described, providing a practical approach for the generation of diverse fluoroalkyl-containing quinoxalin-2(1H)-ones. This methodology exhibits good reaction efficiency, excellent functional group tolerance and extensive structural diversity. In this transformation, difluoromethyl and monofluoroalkyl triphenylphosphonium salts are used as the precursors for providing the corresponding fluoroalkyl radicals via a single electron transfer process under photoredox catalysis.
引用
收藏
页码：5375 / 5382
页数：8
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