Adiposity and sex-specific cancer risk

被引：22

作者：

Rask-Andersen, Mathias ^{[1
]}

Ivansson, Emma ^{[1
]}

Glund, Julia Hoglund ^{[1
]}

Ek, Weronica E. ^{[1
]}

Karlsson, Torgny ^{[1
]}

Johansson, Asa ^{[1
]}

机构：

[1] Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Box 256, S-75105 Uppsala, Sweden

来源：

CANCER CELL | 2023年 / 41卷 / 06期

基金：

瑞典研究理事会; 英国科研创新办公室;

关键词：

BODY-MASS INDEX; PROSTATE-CANCER; MALIGNANT-MELANOMA; OBESITY; METAANALYSIS; ASSOCIATION; REGRESSION; COHORT; EPIDEMIOLOGY; HEIGHT;

D O I：

10.1016/j.ccell.2023.05.010

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat dis-tribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.

引用

页码：1186 / +

页数：17

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