Adiposity and sex-specific cancer risk

被引：22
|
作者：
Rask-Andersen, Mathias [1 ]
Ivansson, Emma [1 ]
Glund, Julia Hoglund [1 ]
Ek, Weronica E. [1 ]
Karlsson, Torgny [1 ]
Johansson, Asa [1 ]
机构：
[1] Uppsala Univ, Dept Immunol Genet & Pathol, Sci Life Lab, Box 256, S-75105 Uppsala, Sweden
来源：
CANCER CELL | 2023年 / 41卷 / 06期
基金：
瑞典研究理事会; 英国科研创新办公室;
关键词：
BODY-MASS INDEX; PROSTATE-CANCER; MALIGNANT-MELANOMA; OBESITY; METAANALYSIS; ASSOCIATION; REGRESSION; COHORT; EPIDEMIOLOGY; HEIGHT;
D O I：
10.1016/j.ccell.2023.05.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Obesity is associated with several types of cancer and fat distribution, which differs dramatically between sexes, has been suggested to be an independent risk factor. However, sex-specific effects on cancer risk have rarely been studied. Here we estimate the effects of fat accumulation and distribution on cancer risk in females and males. We performed a prospective study in 442,519 UK Biobank participants, for 19 cancer types and additional histological subtypes, with a mean follow-up time of 13.4 years. Cox proportional hazard models were used to estimate the effect of 14 different adiposity phenotypes on cancer rates, and a 5% false discovery rate was considered statistically significant. Adiposity-related traits are associated with all but three cancer types, and fat accumulation is associated with a larger number of cancers compared to fat dis-tribution. In addition, fat accumulation or distribution exhibit differential effects between sexes on colorectal, esophageal, and liver cancer.
引用
收藏
页码：1186 / +
页数：17
相关论文
共 50 条
  • [1] Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors
    Fall, Tove
    Hagg, Sara
    Ploner, Alexander
    Maegi, Reedik
    Fischer, Krista
    Draisma, Harmen H. M.
    Sarin, Antti-Pekka
    Benyamin, Beben
    Ladenvall, Claes
    Akerlund, Mikael
    Kals, Mart
    Esko, Tonu
    Nelson, Christopher P.
    Kaakinen, Marika
    Huikari, Ville
    Mangino, Massimo
    Meirhaeghe, Aline
    Kristiansson, Kati
    Nuotio, Marja-Liisa
    Kobl, Michael
    Grallert, Harald
    Dehghan, Abbas
    Kuningas, Maris
    de Vries, Paul S.
    de Bruijn, Renee F. A. G.
    Willems, Sara M.
    Heikkila, Kauko
    Silventoinen, Karri
    Pietilainen, Kirsi H.
    Legry, Vanessa
    Giedraitis, Vilmantas
    Goumidi, Louisa
    Syvanen, Ann-Christine
    Strauch, Konstantin
    Koenig, Wolfgang
    Lichtner, Peter
    Herder, Christian
    Palotie, Aarno
    Menni, Cristina
    Uitterlinden, Andre G.
    Kuulasmaa, Kari
    Havulinna, Aki S.
    Moreno, Luis A.
    Gonzalez-Gross, Marcela
    Evans, Alun
    Tregouet, David-Alexandre
    Yarnell, John W. G.
    Virtamo, Jarmo
    Ferrieres, Jean
    Veronesi, Giovanni
    DIABETES, 2015, 64 (05) : 1841 - 1852
  • [2] Sex-specific Association of Primary Aldosteronism With Visceral Adiposity
    Hatano, Yu
    Sawayama, Nagisa
    Miyashita, Hiroshi
    Kurashina, Tomoyuki
    Okada, Kenta
    Takahashi, Manabu
    Matsumoto, Masatoshi
    Hoshide, Satoshi
    Sasaki, Takahiro
    Nagashima, Shuichi
    Ebihara, Ken
    Mori, Harushi
    Kario, Kazuomi
    Ishibashi, Shun
    JOURNAL OF THE ENDOCRINE SOCIETY, 2022, 6 (08)
  • [3] Sex-specific associations of sex hormone binding globulin and risk of bladder cancer
    Ou, Junyong
    Bi, Hai
    Zhou, Haobin
    Zhang, Zhanyi
    Duan, Peichen
    Yin, Haoming
    Zhou, Zezhen
    Xie, Zhixin
    Tian, Xiaojun
    Ye, Jianfei
    Zhang, Shudong
    OPEN MEDICINE, 2025, 20 (01):
  • [4] Leptin gene variants and colorectal cancer risk: Sex-specific associations
    Chun, Kelsey A.
    Kocarnik, Jonathan M.
    Hardikar, Sheetal S.
    Robinson, Jamaica R.
    Berndt, Sonja, I
    Chan, Andrew T.
    Figueiredo, Jane C.
    Lindor, Noralane M.
    Song, Mingyang
    Schoen, Robert E.
    Hayes, Richard B.
    Potter, John D.
    Nassir, Rami
    Bezieau, Stephane
    Le Marchand, Loic
    Slattery, Martha L.
    White, Emily
    Peters, Ulrike
    Newcomb, Polly A.
    PLOS ONE, 2018, 13 (10):
  • [5] Sex-Specific Associations between Gut Prevotellaceae and Host Genetics on Adiposity
    Cuevas-Sierra, Amanda
    Riezu-Boj, Jose Ignacio
    Guruceaga, Elizabeth
    Milagro, Fermin Ignacio
    Martinez, Jose Alfredo
    MICROORGANISMS, 2020, 8 (06) : 1 - 19
  • [6] Sex-specific effects of central adiposity and inflammatory markers on limbic microstructure
    Metzler-Baddeley, Claudia
    Mole, Jilu P.
    Leonaviciute, Erika
    Sim, Rebecca
    Kidd, Emma J.
    Ertefai, Benyamin
    Kelso-Mitchell, Aurora
    Gidney, Florence
    Fasano, Fabrizio
    Evans, John
    Jones, Derek K.
    Baddeley, Roland J.
    NEUROIMAGE, 2019, 189 : 793 - 803
  • [7] Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran
    Ramezankhani, Azra
    Azizi, Fereidoun
    Hadaegh, Farzad
    BIOLOGY OF SEX DIFFERENCES, 2020, 11 (01)
  • [8] Sex-specific clustering of metabolic risk factors and cancer risk: a longitudinal study in Iran
    Azra Ramezankhani
    Fereidoun Azizi
    Farzad Hadaegh
    Biology of Sex Differences, 11
  • [9] When are sex-specific effects really sex-specific?
    Chin, E. H.
    Christians, J. K.
    JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE, 2015, 6 (05) : 438 - 442
  • [10] Sex-specific Prenatal Programming A Risk for Fibromyalgia?
    Klingmann, P. O.
    Kugler, I.
    Steffke, T. S.
    Bellingrath, S.
    Kudielka, B. M.
    Hellhammer, D. H.
    STRESS, NEUROTRANSMITTERS, AND HORMONES: NEUROENDOCRINE AND GENETIC MECHANISMS, 2008, 1148 : 446 - 455
12345