Indications and Limits of Surgery for Spinal Metastases Derived from Lung Cancer: A Single-Center Experience

被引:2
作者
Terzi, Silvia [1 ]
Trentin, Federica [1 ]
Griffoni, Cristiana [1 ]
Carretta, Elisa [2 ]
Bandiera, Stefano [1 ]
Ferrari, Cristina [3 ]
Vita, Fabio [1 ]
Righi, Alberto [4 ]
Maioli, Margherita [4 ]
De Biase, Dario [5 ]
Monetta, Annalisa [1 ]
Brodano, Giovanni Barbanti [1 ]
Evangelisti, Gisberto [1 ]
Girolami, Marco [1 ]
Pipola, Valerio [1 ]
Gambarotti, Marco [4 ]
Gasbarrini, Alessandro [1 ]
机构
[1] IRCCS Ist Ortoped Rizzoli, Dept Spine Surg, I-40136 Bologna, Italy
[2] IRCCS Ist Ortoped Rizzoli, Dept Programming & Monitoring, I-40136 Bologna, Italy
[3] IRCCS Ist Ortoped Rizzoli, Lab Expt Oncol, I-40136 Bologna, Italy
[4] IRCCS Ist Ortoped Rizzoli, Anat & Pathol Histol Unit, I-40136 Bologna, Italy
[5] Univ Bologna, Dept Pharm & Biotechnol, Mol Diagnost Unit, I-40136 Bologna, Italy
关键词
spinal metastases; non-small-cell lung cancer; spine surgery; survival; quality of life; SURVIVAL; DISEASE; MANAGEMENT;
D O I
10.3390/diagnostics13122093
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Lung cancer is the second most frequently diagnosed cancer in the world, and surgery is an integral part of the treatment for spinal metastases. The aims of this retrospective study were to assess the overall survival of surgically treated patients affected by lung cancer spinal metastases and identify any factors related to a better survival rate. We recruited 56 consecutive patients (34 male and 22 female) surgically treated for metastatic lung cancer in the spine from 2009 to 2019. Surgical indications were based on a previously published and validated flow chart following a multidisciplinary evaluation. We assessed the localization of vertebral metastases, the presence of other bone or visceral metastases, neurological status according to the Frankel score, ambulatory autonomy, and general status, measured with the Karnofsky performance scale. The expected prognosis was retrospectively assessed according to the revised Tokuhashi score. The median survival was 8.1 months, with over a third of patients surviving more than 1 year. We observed a global improvement in all clinical parameters after surgical treatment. The Tokuhashi predictive score did not correlate with survival after surgery. The results of this study suggest that the surgical treatment of symptomatic spinal metastases from lung cancer can improve quality of life, even in patients with a shorter life expectancy, by controlling pain and improving autonomy.
引用
收藏
页数:14
相关论文
共 24 条
[1]   Spinal metastases from lung cancer: Survival depends only on genotype, neurological and personal status, scarcely of surgical resection [J].
Amelot, Aymeric ;
Terrier, Louis-Marie ;
Cristini, Joseph ;
Buffenoir, Kevin ;
Pascal-Moussellard, Hugues ;
Carpentier, Alexandre ;
Bonaccorsi, Raphael ;
Le Nail, Louis-Romee ;
Mathon, Bertrand .
SURGICAL ONCOLOGY-OXFORD, 2020, 34 :51-56
[2]   Spinal extradural metastasis: Review of current treatment options [J].
Bartels, Ronald H. M. A. ;
van der Linden, Yvette M. ;
van der Graaf, Winette T. A. .
CA-A CANCER JOURNAL FOR CLINICIANS, 2008, 58 (04) :245-259
[3]   Essential Concepts for the Management of Metastatic Spine Disease: What the Surgeon Should Know and Practice [J].
Barzilai, Ori ;
Boriani, Stefano ;
Fisher, Charles G. ;
Sahgal, Arjun ;
Verlaan, Jorrit Jan ;
Gokaslan, Ziya L. ;
Lazary, Aron ;
Bettegowda, Chetan ;
Rhines, Laurence D. ;
Laufer, Ilya .
GLOBAL SPINE JOURNAL, 2019, 9 :98S-107S
[4]   Spine Metastasis in Elderly Encouraging Results for Better Survival [J].
Beaufort, Quentin ;
Terrier, Louis-Marie ;
Dubory, Arnaud ;
Le Nail, Louis-Romee ;
Cook, Ann-Rose ;
Cristini, Joseph ;
Buffenoir, Kevin ;
Pascal-Moussellard, Hugues ;
Carpentier, Alexandre ;
Mathon, Bertrand ;
Amelot, Aymeric .
SPINE, 2021, 46 (11) :751-759
[5]  
Cappuccio M, 2008, EUR REV MED PHARMACO, V12, P155
[6]   Clinical features of metastatic bone disease and risk of skeletal morbidity [J].
Coleman, Robert E. .
CLINICAL CANCER RESEARCH, 2006, 12 (20) :6243S-6249S
[7]   Molecular Diagnostic of Solid Tumor Using a Next Generation Sequencing Custom-Designed Multi-Gene Panel [J].
de Biase, Dario ;
Acquaviva, Giorgia ;
Visani, Michela ;
Sanza, Viviana ;
Argento, Chiara M. ;
De Leo, Antonio ;
Maloberti, Thais ;
Pession, Annalisa ;
Tallini, Giovanni .
DIAGNOSTICS, 2020, 10 (04)
[8]   Survival analysis in patients with metastatic spinal disease: the influence of surgery, histology, clinical and neurologic status [J].
de Oliveira, Matheus Fernandes ;
Rotta, Jose Marcus ;
Botelho, Ricardo Vieira .
ARQUIVOS DE NEURO-PSIQUIATRIA, 2015, 73 (04) :330-335
[9]   Structure-Guided Strategies of Targeted Therapies for Patients with EGFR-Mutant Non-Small Cell Lung Cancer [J].
Du, Zhenfang ;
Sun, Jinghan ;
Zhang, Yunkai ;
Hesilaiti, Nigaerayi ;
Xia, Qi ;
Cui, Heqing ;
Fan, Na ;
Xu, Xiaofang .
BIOMOLECULES, 2023, 13 (02)
[10]  
Frankel H L, 1969, Paraplegia, V7, P179