Nitrous oxide-induced subacute combined degeneration of the cord: diagnosis and treatment

被引：34

作者：

Paris, Alvar ^{[1
,2
]}

Lake, Luke ^{[2
]}

Joseph, Albert ^{[2
]}

Workman, Anna ^{[2
]}

Walton, Joseph ^{[2
]}

Hayton, Tom ^{[3
,4
]}

Evangelou, Nikos ^{[5
,6
]}

Lilleker, James B. ^{[7
,8
]}

Ayling, Ruth M. ^{[2
]}

Nicholl, David ^{[9
]}

Noyce, Alastair J. ^{[1
,2
]}

机构：

[1] Queen Mary Univ London, Wolfson Inst Populat Hlth, Fac Med & Dent, Ctr Prevent Diag & Detect,Prevent Neurol Unit, London EC1M 6BQ, England

[2] Barts Hlth NHS Trust, Royal London Hosp, London, England

[3] Univ Hosp Birmingham NHS Fdn Trust, Neurol, Birmingham, England

[4] Natl Inst Hlth Res, Surg Reconstruct & Microbiol Res Ctr, Birmingham, England

[5] Nottingham Univ Hosp NHS Trust, Acad Neurol, Nottingham, England

[6] Univ Nottingham, Sch Med, Mental Hlth & Clin Neurosci Acad Unit, Nottingham, England

[7] Northern Care Alliance NHS Fdn Trust, Manchester Ctr Clin Neurosci, Manchester Acad Hlth Sci Ctr, Muscle Dis Unit, Salford, England

[8] Univ Manchester, Ctr Musculoskeletal Res, Div Musculoskeletal & Dermatol Sci, Manchester, England

[9] Sandwell & West Birmingham NHS Trust, Birmingham, England

来源：

PRACTICAL NEUROLOGY | 2023年 / 23卷 / 03期

关键词：

B12; DEFICIENCY; CLINICAL NEUROLOGY; GAIT; MYELOPATHY; NEUROTOXICOLOGY; SPINAL-CORD; INDUCED NEUROPATHY; ANESTHESIA; MYELONEUROPATHY;

D O I：

10.1136/pn-2022-003631

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Recreational use of nitrous oxide (N2O) has increased rapidly in recent years and is now the second most commonly used recreational drug among young people in the UK. There has been a corresponding rise in cases of nitrous oxide-induced subacute combined degeneration of the cord (N2O-SACD), a pattern of myeloneuropathy usually associated with severe vitamin B-12 deficiency. This can cause serious and permanent disability in young people but, if recognised early, may be effectively treated. All neurologists should be aware of N2O-SACD and its treatment; however, there are currently no agreed guidelines. Based on our experience in East London, an area of high N2O use, we provide practical advice on its recognition, investigation and treatment.

引用

页码：222 / +

页数：8

共 47 条

[1] Nitrous oxide recreational abuse presenting with myeloneuropathy and mimicking Guillain-Barre syndrome [J].