A Rare Case of Pembrolizumab-Associated Graves? Disease

被引：1

作者：

Alqaisi, Sura ^{[1
]}

Rahman, Ali ^{[2
]}

机构：

[1] Mem Healthcare, Internal Med, Pembroke Pines, FL 33024 USA

[2] Mather Hosp, Internal Med, Northwell Hlth, Port Jefferson, NY USA

来源：

CUREUS JOURNAL OF MEDICAL SCIENCE | 2023年 / 15卷 / 02期

关键词：

immune-related adverse events; immune checkpoint inhibitors; hyperthyroidism; thyrotoxicosis; graves? disease; INHIBITION; CANCER;

D O I：

10.7759/cureus.34696

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Immune checkpoint inhibitors (ICPis), such as pembrolizumab (Keytruda??), are associated with the development of several immune-related adverse events (irAEs). Thyroid dysfunction is a common endocrine irAE associated with pembrolizumab; however, Graves??? disease induced by pembrolizumab is extremely rare. Few cases of this condition have been reported in the literature. Here, we report the case of a 50-year-old patient who presented with thyrotoxicosis that was attributed to Graves??? disease secondary to pembrolizumab therapy.

引用

页数：6

共 19 条

[1] Research Status and Outlook of PD-1/PD-L1 Inhibitors for Cancer Therapy [J].

Ai, Leilei ;

Chen, Jian ;

Yan, Hao ;

He, Qiaojun ;

Luo, Peihua ;

Xu, Zhifei ;

Yang, Xiaochun .

DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 :3625-3649

[2] Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline [J].

Brahmer, Julie R. ;

Lacchetti, Christina ;

Schneider, Bryan J. ;

Atkins, Michael B. ;

Brassil, Kelly J. ;

Caterino, Jeffrey M. ;

Chau, Ian ;

Ernstoff, Marc S. ;

Gardner, Jennifer M. ;

Ginex, Pamela ;

Hallmeyer, Sigrun ;

Chakrabarty, Jennifer Holter ;

Leighl, Natasha B. ;

Mammen, Jennifer S. ;

McDermott, David F. ;

Naing, Aung ;

Nastoupil, Loretta J. ;

Phillips, Tanyanika ;

Porter, Laura D. ;

Puzanov, Igor ;

Reichner, Cristina A. ;

Santomasso, Bianca D. ;

Seigel, Carole ;

Spira, Alexander ;

Suarez-Almazor, Maria E. ;

Wang, Yinghong ;

Weber, Jeffrey S. ;

Wolchok, Jedd D. ;

Thompson, John A. .

JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (17) :1714-+

[3] Graves' Disease Induced by Immune Checkpoint Inhibitors: A Case Report and Review of the Literature [J].

Brancatella, Alessandro ;

Viola, Nicola ;

Brogioni, Sandra ;

Montanelli, Lucia ;

Sardella, Chiara ;

Vitti, Paolo ;

Marcocci, Claudio ;

Lupi, Isabella ;

Latrofa, Francesco .

EUROPEAN THYROID JOURNAL, 2019, 8 (04) :192-195

[4] FDA Approval Summary: Pembrolizumab for the First-line Treatment of Patients with MSI-H/dMMR Advanced Unresectable or Metastatic Colorectal Carcinoma [J].

Casak, Sandra J. ;

Marcus, Leigh ;

Fashoyin-Aje, Lola ;

Mushti, Sirisha L. ;

Cheng, Joyce ;

Shen, Yuan-Li ;

Pierce, William F. ;

Her, Leah ;

Goldberg, Kirsten B. ;

Theoret, Marc R. ;

Kluetz, Paul G. ;

Pazdur, Richard ;

Lemery, Steven J. .

CLINICAL CANCER RESEARCH, 2021, 27 (17) :4680-4684

[5] New onset autoimmune diabetes mellitus and hypothyroidism secondary to pembrolizumab in a patient with metastatic lung cancer [J].

Cunha, Clara ;

Silva, Eugenia ;

Vieira, Ana Claudia ;

Saraiva, Catarina ;

Duarte, Sequeira .

ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS, 2022, 2022

[6] Immune checkpoint inhibitors: recent progress and potential biomarkers [J].

Darvin, Pramod ;

Toor, Salman M. ;

Nair, Varun Sasidharan ;

Elkord, Eyad .

EXPERIMENTAL AND MOLECULAR MEDICINE, 2018, 50 :1-11

[7] Incidence of Thyroid-Related Adverse Events in Melanoma Patients Treated With Pembrolizumab [J].

de Filette, Jeroen ;

Jansen, Yanina ;

Schreuer, Max ;

Everaert, Hendrik ;

Velkeniers, Brigitte ;

Neyns, Bart ;

Bravenboer, Bert .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2016, 101 (11) :4431-4439

[8] Pembrolizumab-Induced Thyroiditis: Comprehensive Clinical Review and Insights Into Underlying Involved Mechanisms [J].

Delivanis, Danae A. ;

Gustafson, Michael P. ;

Bornschlegl, Svetlana ;

Merten, Michele M. ;

Kottschade, Lisa ;

Withers, Sarah ;

Dietz, Allan B. ;

Ryder, Mabel .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2017, 102 (08) :2770-2780

[9] Immune checkpoints and their inhibition in cancer and infectious diseases [J].

Dyck, Lydia ;

Mills, Kingston H. G. .

EUROPEAN JOURNAL OF IMMUNOLOGY, 2017, 47 (05) :765-779

[10]

Flynn JP., 2022, PEMBROLIZUMAB

← 1 2 →