Anti-TIF1γ antibody-positive dermatomyositis associated with nivolumab administration in a patient with advanced oesophageal squamous cell carcinoma: A case report and literature review

被引:0
作者
Sakurai, Takuya [1 ]
Takahashi, Junichiro [2 ,3 ]
Komatsu, Teppei [2 ]
Mitsumura, Hidetaka [2 ]
Iguchi, Yasuyuki [2 ]
机构
[1] Jikei Univ, Sch Med, Dept Cardiol, Tokyo, Japan
[2] Jikei Univ, Sch Med, Dept Neurol, Tokyo, Japan
[3] Jikei Univ, Sch Med, Dept Neurol, 3-25-8 Nishi Shinbashi,Minato Ku, Tokyo 1058461, Japan
关键词
TIF1 gamma antibody; dermatomyositis; immune-related adverse events; cancer; paraneoplastic syndrome; CANCER; AUTOANTIBODY;
D O I
10.1093/mrcr/rxad007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
We report a case of anti-transcriptional intermediary factor 1 gamma antibody-positive dermatomyositis following nivolumab treatment. The patient was successfully treated with pulse steroid therapy and high-dose intravenous immunoglobulin, followed by oral glucocorticoid treatment. Immune checkpoint inhibitors, such as nivolumab, may induce not only myositis as an immune-related adverse event but also dermatomyositides as a paraneoplastic syndrome by distracting immune tolerance. Differentiating between pathologies is warranted if patients develop myositis after immune checkpoint inhibitor administration.
引用
收藏
页码:416 / 421
页数:6
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