A research review of experimental animal models with myelodysplastic syndrome

被引：0

作者：

Chen, Gen-Wang ^{[1
]}

Chen, Mei-Na ^{[2
]}

Liu, Lei ^{[1
]}

Zheng, Yu-Yu ^{[1
]}

Wang, Jin-Peng ^{[1
]}

Gong, Si-Si ^{[1
]}

Huang, Rong-Fu ^{[1
]}

Fan, Chun-Mei ^{[1
]}

Chen, Yue-Zu ^{[2
]}

机构：

[1] Fujian Med Univ, Donghai Hosp Dist, Clin Lab & Med Diagnost Lab, Affiliated Hosp 2, Quanzhou 362000, Peoples R China

[2] Quanzhou Hosp Tradit Chinese Med, Clin Lab, Quanzhou 362000, Peoples R China

来源：

CLINICAL & TRANSLATIONAL ONCOLOGY | 2023年 / 25卷 / 01期

关键词：

Myelodysplastic syndrome (MDS); Animal model; Spontaneous MDS model; ACUTE MYELOID-LEUKEMIA; EMBRYONIC-DEVELOPMENT; IN-VITRO; MOUSE; MICE; MDS; EVI1; MUTATIONS; THERAPY; NUCLEOPHOSMIN;

D O I：

10.1007/s12094-022-02931-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Myelodysplastic syndrome (MDS) consists of a group of hematologic tumors that are derived from the clonal proliferation of hematopoietic stem cells, featuring abnormal hematopoietic cell development and ineffective hematopoiesis. Animal models are an important scientific research platform that has been widely applied in the research of human diseases, especially tumors. Animal models with MDS can simulate characteristic human genetic variations and tumor phenotypes. They also provide a reliable platform for the exploration of the pathogenesis and diagnostic markers of MDS as well as for a drug efficacy evaluation. This paper reviews the research status of three animal models and a new spontaneous mouse model with MDS.

引用

页码：105 / 113

页数：9

共 55 条

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