The 2023 Orthopedic Research Society's international consensus meeting on musculoskeletal infection: Summary from the in vitro section

被引：11

作者：

Hickok, Noreen J. ^{[1
]}

Li, Bingyun ^{[2
]}

Oral, Ebru ^{[3
]}

Zaat, Sebastian A. J. ^{[4
]}

Armbruster, David A. ^{[5
]}

Atkins, Gerald J. ^{[6
]}

Chen, Antonia F. ^{[7
]}

Coraca-Huber, Debora C. ^{[8
]}

Dai, Tianhong ^{[9
]}

Greenfield, Edward M. ^{[10
]}

Kasinath, Rajendra ^{[11
]}

Libera, Matthew ^{[12
]}

Marques, Claudia N. H. ^{[13
]}

Moriarty, T. Fintan ^{[14
]}

Scott Phillips, K. ^{[15
]}

Raghuraman, Kapil ^{[16
]}

Ren, Dacheng ^{[17
]}

Rimondini, Lia ^{[18
]}

Saeed, Kordo ^{[19
,20
]}

Schaer, Thomas P. ^{[21
]}

Schwarz, Edward M. ^{[22
]}

Spiegel, Christopher ^{[23
]}

Stoodley, Paul ^{[24
]}

Truong, Vi Khanh ^{[25
]}

Tsang, Shao-Ting Jerry ^{[26
]}

Wildemann, Britt ^{[27
]}

Zelmer, Anja R. ^{[6
]}

Zinkernagel, Annelies S. ^{[28
]}

机构：

[1] Thomas Jefferson Univ, Dept Biochem & Mol Biol, Dept Orthopaed Surg, Philadelphia, PA 19107 USA

[2] West Virginia Univ, Sch Med, Dept Orthopaed, Morgantown, WV 26506 USA

[3] Harvard Med Sch, Massachusetts Gen Hosp, Harris Orthopaed Lab, Boston, MA 02115 USA

[4] Univ Amsterdam, Amsterdam Inst Infect & Immun, Dept Med Microbiol & Infect Prevent, Amsterdam UMC, Amsterdam, Netherlands

[5] West Chester Univ, Anthropol & Sociol, W Chester, PA USA

[6] Univ Adelaide, Ctr Orthopaed & Trauma Res, Adelaide, SA, Australia

[7] Harvard Med Sch, Brigham & Womens Hosp, Dept Orthopaed, Boston, MA 02115 USA

[8] Med Univ Innsbruck, Univ Hosp Orthoped & Traumatol, Res Lab Biofilms & Implant Associated Infect BIOFI, Innsbruck, Austria

[9] Harvard Med Sch, Massachusetts Gen Hosp, Wellman Ctr Photomed, Boston, MA 02129 USA

[10] Indiana Univ Sch Med, Indiana Ctr Musculoskeletal Hlth, Indianapolis, IN USA

[11] Indiana Univ, Higher Educ & Student Affairs, Indiana, PA USA

[12] Stevens Inst Technol, Dept Chem Engn & Mat Sci, Hoboken, NJ USA

[13] Binghamton Univ, Dept Biol Sci, Binghamton Biofilm Res Ctr, Binghamton, NY 13902 USA

[14] AO Res Inst Davos, Davos, Switzerland

[15] Food & Drug Adm, Div Biol Standard & Qual Control, Off Compliance & Biol Qual, Ctr Biol Evaluat & Res, Silver Spring, MD 20993 USA

[16] Austin Radiol Assoc, Austin, TX USA

[17] Syracuse Univ, Dept Biomed & Chem Engn, Syracuse, NY USA

[18] Univ Piemonte Orientale, Dept Hlth Sci, Novara, Italy

[19] Univ Hosp Southampton NHS Fdn Trust, Gastroenterol, Southampton, England

[20] Univ Southampton, Southampton, Hampshire, England

[21] Univ Penn, New Bolton Ctr, Dept Clin Studies, Kennett Sq, PA USA

[22] Univ Rochester, Ctr Musculoskeletal Res, Rochester, NY USA

[23] Med Univ Innsbruck, Univ Hosp Orthoped & Traumatol, Res Lab Biofilms & Implant Associated Infect BIOFI, Innsbruck, Austria

[24] Ohio State Univ, Dept Microbial Infect & Immun, Columbus, OH USA

[25] Flinders Univ S Australia, Coll Med & Publ Hlth, Biomed Nanoengn Lab, Bedford Pk, SA 5042, Australia

[26] Univ Edinburgh, Dept Trauma & Orthopaed Surg, Edinburgh, Midlothian, Scotland

[27] Friedrich Schiller Univ Jena, Jena Univ Hosp, Dept Trauma Hand & Reconstruct Surg, Expt Trauma Surg, Jena, Germany

[28] Univ Zurich, Univ Hosp Zurich, Dept Infect Dis & Hosp Epidemiol, Zurich, Switzerland

来源：

JOURNAL OF ORTHOPAEDIC RESEARCH | 2024年 / 42卷 / 03期

关键词：

antimicrobial; biofilm; in vitro models; international consensus meeting (ICM); musculoskeletal infection (MSKI); BIOFILM; STERILIZATION; SURFACE; RACE;

D O I：

10.1002/jor.25774

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Antimicrobial strategies for musculoskeletal infections are typically first developed with in vitro models. The In Vitro Section of the 2023 Orthopedic Research Society Musculoskeletal Infection international consensus meeting (ICM) probed our state of knowledge of in vitro systems with respect to bacteria and biofilm phenotype, standards, in vitro activity, and the ability to predict in vivo efficacy. A subset of ICM delegates performed systematic reviews on 15 questions and made recommendations and assessment of the level of evidence that were then voted on by 72 ICM delegates. Here, we report recommendations and rationale from the reviews and the results of the internet vote. Only two questions received a >= 90% consensus vote, emphasizing the disparate approaches and lack of established consensus for in vitro modeling and interpretation of results. Comments on knowledge gaps and the need for further research on these critical MSKI questions are included.

引用

页码：512 / 517

页数：6

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