Diagnosis of neuropsychiatry disorder in patients with anti-MDA5 antibody dermatomyositis: A case report

被引：0
作者：
Xing, Yida [1 ]
Liu, Changyan [1 ]
Xu, Mingxi [1 ]
Zhao, Lin [1 ]
Kong, Xiaodan [1 ,2 ]
机构：
[1] Dalian Med Univ, Dept Rheumatol, Affiliated Hosp 2, Dalian, Peoples R China
[2] Dalian Med Univ, Affiliated Hosp 2, 467 Zhongshan Rd, Dalian 116027, Liaoning, Peoples R China
来源：
HELIYON | 2023年 / 9卷 / 12期
关键词：
Anti-melanoma differentiation-associated gene; 5; dermatomyositis; Neuropsychiatric disorder; Autoimmune disease; Gottron papules; Tacrolimus; INTERSTITIAL LUNG-DISEASE; GENE; 5; ANTIBODIES; AUTOANTIBODIES; ASSOCIATION;
D O I：
10.1016/j.heliyon.2023.e22935
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Anti-melanoma differentiation-associated gene 5 (MDA5) dermatomyositis (DM) is a rare disease that can be easily misdiagnosed. Anti-MDA5 dermatomyositis is a subtype of DM. It is distinguished by the presence of significant mucocutaneous characteristics, palmar papules, panniculitis, interstitial lung disease (ILD), and clinically amyopathic dermatomyositis (CADM). When combined with rapidly progressing ILD (RP-ILD), anti-MDA5 DM can be fatal. The literature indicates that nervous system involvement is uncommon in patients with anti-MDA5 DM. We report a case of anti-MDA5 DM with neuropsychiatric abnormalities and ILD. The patient suffered from persistent worsening mental disorders, while his ILD was relatively stable. The patient's neuropsychiatric abnormalities gradually subsided after receiving treatment with glucocorticoids, immunoglobulins, and immunosuppressants, leaving only a slow response and memory loss.
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页数：6
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