MiR-7-5p targeted Rb regulating cell cycle is involved in hydroquinone-induced malignant progression in human lymphoblastoid TK6 cells

被引：0

作者：

Zhai, Lu ^{[1
]}

Gao, Yuting ^{[1
]}

Cui, Zheming ^{[1
]}

Chen, Lin ^{[1
]}

Yu, Lingxue ^{[1
]}

Guo, Pu ^{[1
]}

Zhu, Delong ^{[1
]}

Tang, Huanwen ^{[1
,2
]}

Liu, Xin ^{[1
]}

Luo, Hao ^{[1
]}

机构：

[1] Guangdong Med Univ, Sch Publ Hlth, Dept Environm & Occupat Hlth, Dongguan Key Lab Environm Med, Dongguan, Peoples R China

[2] Guangdong Med Univ, Dongguan Affiliated Hosp 1, Dongguan, Peoples R China

来源：

FOOD AND CHEMICAL TOXICOLOGY | 2023年 / 182卷

基金：

中国国家自然科学基金;

关键词：

Hydroquinone; miR-7-5p; Cell cycle; Rb; TUMOR-SUPPRESSOR; PROLIFERATION; APOPTOSIS; LEUKEMIA; BENZENE; DISEASE;

D O I：

10.1016/j.fct.2023.114186

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

MiR-7-5p has been demonstrated to inhibit tumorigenesis by limiting tumor cell proliferation, migration and invasion. However, its role in countering hydroquinone (HQ)-induced malignant phenotype of TK6 cells has remained unclear. The present study aimed to investigate whether miR-7-5p overexpression could restrain the malignant phenotype in TK6 cells exposed to HQ. The results displayed that HQ suppressed the expression of miR-7-5p and promoted cell cycle progression. Further investigations confirmed that miR-7-5p could decelerate the cell cycle progression by targeting Rb after acute HQ exposure. Through the regulation of the Rb/E2F1 signaling pathway, the overexpression of miR-7-5p mitigated HQ-induced malignant phenotype in TK6 cells by impeding cell cycle progression. In conclusion, miR-7-5p overexpression appears to be involved in HQ-induced malignant transformation by suppressing Rb/E2F1 signaling pathway, resulting in a deceleration of the cell cycle progression.

引用

页数：8

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