Background: Currently, echocardiography has become an integral part of pediatric cardiology and cardiac surgery. In echocardiography, in addition to qualitative assessment, quantitative assessment is of great importance. In a growing body, internal organs, including the heart, change in size accordingly. Until now, studies on quantitative echocardiography in children have been conducted mainly in Europe and North America. Taking into account that, in addition to anthropometric parameters, factors such as climate, habitat, and race affect the size of the heart, it becomes necessary to develop standards specific to children living in Uzbekistan, located in Central Asia. Aim of review: The primary aim of this review is to underscore the necessity of creating population-specific reference parameters for echocardiographic measurements in Uzbek children. It emphasizes the unique challenges in interpreting cardiac measurements during childhood due to growth-related variations and discusses the utility of Z-scores as a tool for assessing deviations from normality. Key scientific concepts of review: Conducting research to establish precise guidelines for pediatric echocardiography examinations and measurements is of paramount significance. Different populations have different standards, so it is important to take into account ethnic characteristics. In order to establish accurate standards for cardiac measurements in children of Uzbekistan, it is necessary to conduct a large-scale study on healthy children of this country.