Plasmacytoid dendritic cell expansion in myeloid neoplasms: A novel distinct subset of myeloid neoplasm?

被引：5

作者：

Peng, Juan ^{[1
,2
]}

He, Shaolong ^{[1
,3
]}

Yang, Xingcheng ^{[1
,2
]}

Huang, Liang ^{[1
,2
]}

Wei, Jia ^{[1
,2
,3
,4
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Hematol, Wuhan 430000, Hubei, Peoples R China

[2] Immunotherapy Res Ctr Hematol Dis Hubei Prov, Wuhan 430030, Hubei, Peoples R China

[3] Shanxi Acad Med Sci, Tongji Shanxi Hosp, Shanxi Bethune Hosp, Dept Hematol, Taiyuan 030032, Peoples R China

[4] Shanxi Acad Med Sci, Shanxi Bethune Hosp, Sino German Joint Oncol Res Lab, Taiyuan 030032, Shanxi, Peoples R China

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2023年 / 192卷

基金：

中国国家自然科学基金;

关键词：

Plasmacytoid dendritic cell; Acute myeloid leukemia; Myelodysplastic syndrome; CD123; JUVENILE MYELOMONOCYTIC LEUKEMIA; ANTIBODY-DRUG CONJUGATE; BONE-MARROW; ANTILEUKEMIA ACTIVITY; IN-VITRO; T-CELLS; PHASE-I; MUTATIONS; PTPN11; EXPRESSION;

D O I：

10.1016/j.critrevonc.2023.104186

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Plasmacytoid dendritic cells (pDCs) are a specific dendritic cell type stemming from the myeloid lineage. Clinically and pathologically, neoplasms associated with pDCs are classified as blastic plasmacytoid dendritic cell neoplasm (BPDCN), mature plasmacytoid dendritic myeloid neoplasm (MPDMN) and pDC expansion in myeloid neoplasms (MNs). BPDCN was considered a rare and aggressive neoplasm in the 2016 World Health Organization (WHO) classification. MPDMN, known as mature pDC-derived neoplasm, is closely related to MNs and was first recognized in the latest 2022 WHO classification, proposing a new concept that acute myeloid leukemia cases could show clonally expanded pDCs (pDC-AML). With the advances in detection techniques, an increasing number of pDC expansion in MNs have been reported, but whether the pathogenesis is similar to that of MPDMN remains unclear. This review focuses on patient characteristics, diagnosis and treatment of pDC expansion in MNs to gain further insight into this novel and unique provisional subtype.

引用

页数：12

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