Lesional skin of seborrheic dermatitis patients is characterized by skin barrier dysfunction and correlating alterations in the stratum corneum ceramide composition

被引：13

作者：

Rousel, Jannik ^{[1
,2
]}

Nadaban, Andreea ^{[2
]}

Saghari, Mahdi ^{[1
,3
]}

Pagan, Lisa ^{[1
,3
]}

Zhuparris, Ahnjili ^{[1
,2
,3
,4
]}

Theelen, Bart ^{[5
]}

Gambrah, Tom ^{[1
]}

van Der Wall, Hein E. C. ^{[1
]}

Vreeken, Rob J. ^{[6
]}

Feiss, Gary L. ^{[7
]}

Niemeyer-van der Kolk, Tessa ^{[1
]}

Burggraaf, Jacobus ^{[1
,2
,3
]}

van Doorn, Martijn B. A. ^{[1
,8
]}

Bouwstra, Joke A. ^{[2
]}

Rissmann, Robert ^{[1
,2
,3
,9
]}

机构：

[1] Ctr Human Drug Res, Leiden, Netherlands

[2] Leiden Univ, Leiden Acad Ctr Drug Res, Leiden, Netherlands

[3] Leiden Univ, Med Ctr, Leiden, Netherlands

[4] Leiden Univ, Leiden Inst Adv Comp Sci, Leiden, Netherlands

[5] Westerdijk Fungal Biodivers Inst, Utrecht, Netherlands

[6] Maastricht Univ, Maastricht Multimodal Mol Imaging Inst, Maastricht, Netherlands

[7] Cutanea Life Sci, Wayne, PA USA

[8] Erasmus MC, Dept Dermatol, Rotterdam, Netherlands

[9] Ctr Human Drug Res, Zernikedreef 8, NL-2333 CL Leiden, Netherlands

来源：

EXPERIMENTAL DERMATOLOGY | 2024年 / 33卷 / 01期

关键词：

barrier; ceramides; Malassezia; seborrheic dermatitis; staphylococcus; TRANSEPIDERMAL WATER-LOSS; MALASSEZIA; ERYTHEMA; ENZYMES; LIPIDS;

D O I：

10.1111/exd.14952

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Seborrheic dermatitis (SD) is a chronic inflammatory skin disease characterized by erythematous papulosquamous lesions in sebum rich areas such as the face and scalp. Its pathogenesis appears multifactorial with a disbalanced immune system, Malassezia driven microbial involvement and skin barrier perturbations. Microbial involvement has been well described in SD, but skin barrier involvement remains to be properly elucidated. To determine whether barrier impairment is a critical factor of inflammation in SD alongside microbial dysbiosis, a cross-sectional study was performed in 37 patients with mild-to-moderate facial SD. Their lesional and non-lesional skin was comprehensively and non-invasively assessed with standardized 2D-photography, optical coherence tomography (OCT), microbial profiling including Malassezia species identification, functional skin barrier assessments and ceramide profiling. The presence of inflammation was established through significant increases in erythema, epidermal thickness, vascularization and superficial roughness in lesional skin compared to non-lesional skin. Lesional skin showed a perturbed skin barrier with an underlying skewed ceramide subclass composition, impaired chain elongation and increased chain unsaturation. Changes in ceramide composition correlated with barrier impairment indicating interdependency of the functional barrier and ceramide composition. Lesional skin showed significantly increased Staphylococcus and decreased Cutibacterium abundances but similar Malassezia abundances and mycobial composition compared to non-lesional skin. Principal component analysis highlighted barrier properties as main discriminating features. To conclude, SD is associated with skin barrier dysfunction and changes in the ceramide composition. No significant differences in the abundance of Malassezia were observed. Restoring the cutaneous barrier might be a valid therapeutic approach in the treatment of facial SD.

引用

页数：12

共 72 条

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