Plasticity of Dendritic Spines Underlies Fear Memory

被引:1
|
作者
Choi, Ja Eun [1 ]
Kaang, Bong-Kiun [1 ,2 ]
机构
[1] Seoul Natl Univ, Sch Biol Sci, Seoul, South Korea
[2] Seoul Natl Univ, Sch Biol Sci, 1 Gwanangno, Seoul 08826, South Korea
来源
NEUROSCIENTIST | 2024年 / 30卷 / 06期
基金
新加坡国家研究基金会;
关键词
dendritic spines; synaptic plasticity; structural plasticity; fear memory; tools applied in synapses; LONG-TERM POTENTIATION; SYNAPTIC PLASTICITY; PROTEIN-SYNTHESIS; STRUCTURAL PLASTICITY; LASTING POTENTIATION; PYRAMIDAL CELLS; SILENT SYNAPSES; ENGRAM CELLS; ACTIVATION; ACTIN;
D O I
10.1177/10738584231185530
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The brain has the powerful ability to transform experiences into anatomic maps and continuously integrate massive amounts of information to form new memories. The manner in which the brain performs these processes has been investigated extensively for decades. Emerging reports suggest that dendritic spines are the structural basis of information storage. The complex orchestration of functional and structural dynamics of dendritic spines is associated with learning and memory. Owing to advancements in techniques, more precise observations and manipulation enable the investigation of dendritic spines and provide clues to the challenging question of how memories reside in dendritic spines. In this review, we summarize the remarkable progress made in revealing the role of dendritic spines in fear memory and the techniques used in this field.
引用
收藏
页码:690 / 703
页数:14
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