Emerging role of inositol monophosphatase in cancer

被引：3
|
作者：
Chen, Qian [1 ,2 ]
Shen, Liangfang [1 ,2 ]
Li, Shan [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Geriatr, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[3] 87 Xiangya Rd, Changsha 410008, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 161卷
关键词：
IMPase; IMPA1; IMPA2; Myo-inositol; Cancer; MYOINOSITOL MONOPHOSPHATASE; IMPA2; GENE; BIPOLAR DISORDER; BREAST-CANCER; LITHIUM; ASSOCIATION; EXPRESSION; CELLS; RISK; SCHIZOPHRENIA;
D O I：
10.1016/j.biopha.2023.114442
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Inositol monophosphatase (IMPase) is an enzyme with two homologs-IMPA1 and IMPA2-that is responsible for dephosphorylating myo-inositol monophosphate to generate myo-inositol. IMPase has been extensively studied in neuropsychiatric diseases and is regarded as a susceptibility gene. Recently, emerging evidence has implied that IMPase is linked to cancer development and progression and correlates with patient survival outcomes. Interestingly, whether it acts as a tumor-promoter or tumor-suppressor is inconsistent among different research studies. In this review, we summarize the latest findings on IMPase in cancer, focusing on exploring the underlying mechanisms for its pro- and anticancer roles. In addition, we discuss the potential methods of IMPase regulation in cancer cells and the possible approaches for IMPase intervention in clinical practice.
引用
收藏
页数：10
相关论文
共 50 条
  • [31] Yeast inositol mono- and trisphosphate levels are modulated by inositol monophosphatase activity and nutrients
    Navarro-Aviñó, JP
    Bellés, JM
    Serrano, R
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2003, 302 (01) : 41 - 45
  • [32] Association analysis between polymorphisms in the myo-inositol monophosphatase 2 (IMPA2) gene and bipolar disorder
    Bloch, Paul J.
    Weller, Andrew E.
    Doyle, Glenn A.
    Ferraro, Thomas N.
    Berrettini, Wade H.
    Hodge, Rachel
    Lohoff, Falk W.
    PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2010, 34 (08) : 1515 - 1519
  • [33] Inhibition of inositol monophosphatase by lithium chloride induces selective macrophage apoptosis in atherosclerotic plaques
    De Meyer, Inge
    Martinet, Wim
    Van Hove, Cor E.
    Schrijvers, Dorien M.
    Hoymans, Vicky Y.
    Van Vaeck, Luc
    Fransen, Paul
    Bult, Hidde
    De Meyer, Guido R. Y.
    BRITISH JOURNAL OF PHARMACOLOGY, 2011, 162 (06) : 1410 - 1423
  • [34] Cerebrospinal fluid inositol monophosphatase: Elevated activity in depression and neuroleptic-treated schizophrenia
    Atack, JR
    Levine, J
    Belmaker, RH
    BIOLOGICAL PSYCHIATRY, 1998, 44 (06) : 433 - 437
  • [35] The emerging role of β-secretases in cancer
    Farris, Francesco
    Matafora, Vittoria
    Bachi, Angela
    JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2021, 40 (01)
  • [36] MECHANISM OF INOSITOL MONOPHOSPHATASE, THE PUTATIVE TARGET OF LITHIUM-THERAPY
    POLLACK, SJ
    ATACK, JR
    KNOWLES, MR
    MCALLISTER, G
    RAGAN, CI
    BAKER, R
    FLETCHER, SR
    IVERSEN, LL
    BROUGHTON, HB
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (13) : 5766 - 5770
  • [37] Inhibition of myo-inositol monophosphatase isoforms by aromatic phosphonates
    Ganzhorn, AJ
    Hoflack, J
    Pelton, PD
    Strasser, F
    Chanal, MC
    Piettre, SR
    BIOORGANIC & MEDICINAL CHEMISTRY, 1998, 6 (10) : 1865 - 1874
  • [38] Emerging role of different DNA methyltransferases in the pathogenesis of cancer
    Liu, Pengcheng
    Yang, Fan
    Zhang, Lizhi
    Hu, Ying
    Chen, Bangjie
    Wang, Jianpeng
    Su, Lei
    Wu, Mingyue
    Chen, Wenjian
    FRONTIERS IN PHARMACOLOGY, 2022, 13
  • [39] Brain inositol monophosphatase identified as a galactose 1-phosphatase
    Parthasarathy, R
    Parthasarathy, L
    Vadnal, R
    BRAIN RESEARCH, 1997, 778 (01) : 99 - 106
  • [40] Emerging Role of Migration and Invasion Enhancer 1 (MIEN1) in Cancer Progression and Metastasis
    Kushwaha, Prem Prakash
    Gupta, Sanjay
    Singh, Atul Kumar
    Kumar, Shashank
    FRONTIERS IN ONCOLOGY, 2019, 9
12345