Emerging role of inositol monophosphatase in cancer

被引：3
|
作者：
Chen, Qian [1 ,2 ]
Shen, Liangfang [1 ,2 ]
Li, Shan [1 ,2 ,3 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Oncol, Changsha, Peoples R China
[2] Cent South Univ, Xiangya Hosp, Dept Geriatr, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
[3] 87 Xiangya Rd, Changsha 410008, Peoples R China
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 161卷
关键词：
IMPase; IMPA1; IMPA2; Myo-inositol; Cancer; MYOINOSITOL MONOPHOSPHATASE; IMPA2; GENE; BIPOLAR DISORDER; BREAST-CANCER; LITHIUM; ASSOCIATION; EXPRESSION; CELLS; RISK; SCHIZOPHRENIA;
D O I：
10.1016/j.biopha.2023.114442
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Inositol monophosphatase (IMPase) is an enzyme with two homologs-IMPA1 and IMPA2-that is responsible for dephosphorylating myo-inositol monophosphate to generate myo-inositol. IMPase has been extensively studied in neuropsychiatric diseases and is regarded as a susceptibility gene. Recently, emerging evidence has implied that IMPase is linked to cancer development and progression and correlates with patient survival outcomes. Interestingly, whether it acts as a tumor-promoter or tumor-suppressor is inconsistent among different research studies. In this review, we summarize the latest findings on IMPase in cancer, focusing on exploring the underlying mechanisms for its pro- and anticancer roles. In addition, we discuss the potential methods of IMPase regulation in cancer cells and the possible approaches for IMPase intervention in clinical practice.
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页数：10
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