Measuring cell deformation by microfluidics

被引：10
作者：
An, Ling [1 ]
Ji, Fenglong [2 ]
Zhao, Enming [1 ]
Liu, Yi [1 ]
Liu, Yaling [3 ,4 ]
机构：
[1] Dali Univ, Sch Engn, Dali, Yunnan, Peoples R China
[2] Wuyi Univ, Sch Text Mat & Engn, Jiangmen, Guangdong, Peoples R China
[3] Lehigh Univ, Dept Bioengn, Bethlehem, PA 18015 USA
[4] Lehigh Univ, Dept Mech Engn & Mech, Bethlehem, PA 18015 USA
来源：
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY | 2023年 / 11卷
关键词：
microfluidics; cell deformation; cell imaging; high-throughput analysis; cell mechanical characterization; RED-BLOOD-CELLS; CIRCULATING TUMOR-CELLS; LABEL-FREE SEPARATION; CANCER-CELLS; MECHANICAL CHARACTERIZATION; DEFORMABILITY; CYTOMETRY; DEVICE; CHIP; BIOMECHANICS;
D O I：
10.3389/fbioe.2023.1214544
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Microfluidics is an increasingly popular method for studying cell deformation, with various applications in fields such as cell biology, biophysics, and medical research. Characterizing cell deformation offers insights into fundamental cell processes, such as migration, division, and signaling. This review summarizes recent advances in microfluidic techniques for measuring cellular deformation, including the different types of microfluidic devices and methods used to induce cell deformation. Recent applications of microfluidics-based approaches for studying cell deformation are highlighted. Compared to traditional methods, microfluidic chips can control the direction and velocity of cell flow by establishing microfluidic channels and microcolumn arrays, enabling the measurement of cell shape changes. Overall, microfluidics-based approaches provide a powerful platform for studying cell deformation. It is expected that future developments will lead to more intelligent and diverse microfluidic chips, further promoting the application of microfluidics-based methods in biomedical research, providing more effective tools for disease diagnosis, drug screening, and treatment.
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页数：16
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