Antimicrobial Susceptibility of Community-Acquired Urine Bacterial Isolates in French Amazonia

被引:4
作者
NkontCho, Flaubert [1 ]
Sainte-Rose, Vincent [2 ]
Abboud, Philippe [3 ]
Portecop, Patrick [4 ]
Pujo, Jean Marc [5 ]
Cook, Fabrice [6 ]
Walter, Gaelle [3 ]
Mounier, Roman [7 ]
Resiere, Dabor [8 ]
Houcke, Stephanie [6 ]
Demar, Magalie [2 ,9 ]
Kallel, Hatem [6 ,9 ,10 ]
Djossou, Felix [3 ,9 ]
机构
[1] Cayenne Gen Hosp, Pharm Dept, Cayenne, French Guiana, France
[2] Cayenne Gen Hosp, Lab Microbiol, Cayenne, French Guiana, France
[3] Cayenne Gen Hosp, Trop & Infect Dis Dept, Cayenne, French Guiana, France
[4] Guadeloupe Univ Hosp, Emergency Dept, Pointe A Pitre, Guadeloupe, France
[5] Cayenne Gen Hosp, Emergency Dept, Cayenne, French Guiana, France
[6] Cayenne Gen Hosp, Intens Care Unit, Cayenne, French Guiana, France
[7] Paris Univ, Neurointens Care Unit, GHU Paris, Paris, France
[8] Martinique Univ Hosp, Intens Care Unit, Fort De France, Martinique, France
[9] Univ Guyane, Trop Biome & Immunopathol CNRS, INSERM 1019, UMR 9017, Cayenne, French Guiana, France
[10] Cayenne Gen Hosp, Intens Care Unit, 6 Ave Flamboyants, F-97306 Cayenne, French Guiana, France
关键词
TRACT-INFECTIONS; ESCHERICHIA-COLI; RISK-FACTORS; ANTIBIOTIC-RESISTANCE; MANAGEMENT; EPIDEMIOLOGY; ENTEROBACTERIACEAE; PREVALENCE; DIAGNOSIS; IMPACT;
D O I
10.4269/ajtmh.22-0242
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Bacterial resistance in community-acquired urinary tract infections (UTIs) is increasing worldwide. Our study aimed to assess the microbiological epidemiology and antimicrobial susceptibility patterns of community-acquired urine bacterial isolates in French Amazonia. Our study is retrospective. It was conducted from January 2015 to December 2019 in the microbiology laboratory of the Cayenne General Hospital (French Guiana). It includes all positive urine samples from adult (> 18 years) outpatients (N 5 2,533). Isolated microorganisms were Gram-negative rods in 83.9%, mainly Enterobacterales (98.4%). The main isolated bacteria were Escherichia coli (58.7%) and Klebsiella pneumoniae (13.3%). Among the isolated E. coli, 37.2% were susceptible to amoxicillin, 77.9% to amoxicillin/clavulanic acid, 94.9% to cefotaxime, 78.9% to ofloxacin, and 98.9% to nitrofurantoin. In 106 cases (5.1%), isolated Enterobacterales were extendedspectrum 6-lactamase producers (5% of E. coli and 8.9% of K. pneumoniae). Overall, high levels of cross- and co-resistance were registered. The main isolated Gram-positive bacteria was Staphylococcus saprophyticus (28.9%). It was resistant to oxacillin in 52.5% of cases and susceptible to nitrofurantoin in 99.1% of cases. Patients with S. saprophyticus were young women in almost all cases. In conclusion, the most isolated microorganisms from outpatient urinalyses were E. coli and K. pneumoniae. They showed a high resistance rate to amoxicillin, but they were susceptible to the most remaining antibiotics. S. saprophyticus was isolated mainly in young women and was resistant to oxacillin in half of the cases. Interestingly, nitrofurantoin was active against most isolated organisms and can be considered as empirical treatment in uncomplicated UTIs.
引用
收藏
页码:927 / 935
页数:9
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