A field guide to flow chemistry for synthetic organic chemists

被引：173

作者：

Capaldo, Luca ^{[1
]}

Wen, Zhenghui ^{[1
]}

Noel, Timothy ^{[1
]}

机构：

[1] Univ Amsterdam, Van T Hoff Inst Mol Sci HIMS, Flow Chem Grp, NL-1098 XH Amsterdam, Netherlands

来源：

CHEMICAL SCIENCE | 2023年 / 14卷 / 16期

关键词：

HIGH-THROUGHPUT EXPERIMENTATION; CHEMICAL-REACTIONS; OPTIMIZATION; SCALE; RUFINAMIDE; AUTOMATION; PLATFORM; REACTOR; SYSTEM; TECHNOLOGY;

D O I：

10.1039/d3sc00992k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Flow chemistry has unlocked a world of possibilities for the synthetic community, but the idea that it is a mysterious "black box" needs to go. In this review, we show that several of the benefits of microreactor technology can be exploited to push the boundaries in organic synthesis and to unleash unique reactivity and selectivity. By "lifting the veil" on some of the governing principles behind the observed trends, we hope that this review will serve as a useful field guide for those interested in diving into flow chemistry.

引用

页码：4230 / 4247

页数：18

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