circPTPN12 promotes the progression and sunitinib resistance of renal cancer via hnRNPM/IL-6/STAT3 pathway

被引：6
|
作者：
Shou, Yi [1 ,2 ,3 ]
Yue, Changjie [1 ,2 ]
Wang, Qi [1 ,2 ]
Liu, Jingchong [1 ,2 ]
Xu, Jiaju [1 ,2 ]
Miao, Qi [1 ,2 ]
Liu, Di [1 ,2 ]
Yang, Hongmei [1 ,4 ]
Liu, Yuenan [1 ,2 ]
Zhang, Xiaoping [1 ,2 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Dept Urol, Wuhan 430022, Peoples R China
[2] Huazhong Univ Sci & Technol, Inst Urol Surg, Tongji Med Coll, Wuhan 430022, Peoples R China
[3] Zhejiang Univ, Sir Run Run Shaw Hosp, Dept Urol, Sch Med, Hangzhou 310016, Peoples R China
[4] Huazhong Univ Sci & Technol, Sch Basic Med, Dept Pathogen Biol, Wuhan 430030, Peoples R China
来源：
CELL DEATH & DISEASE | 2023年 / 14卷 / 03期
基金：
中国国家自然科学基金;
关键词：
CELL CARCINOMA; AXIS;
D O I：
10.1038/s41419-023-05717-z
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Renal cell carcinoma (RCC) is characterized by the difficulties in early diagnosis and the propensity to metastases. For advanced RCC, sunitinib targeted therapy is the clinically recommended first-line drug and the major challenge of sunitinib treatment is adaptive resistance. Therefore, it is imperative to research the mechanisms underlying sunitinib resistance. In this study, we discovered that circPTPN12 was highly expressed in RCC tissues and was associated with poorer clinical outcomes. circPTPN12 could promote the proliferation, migration, invasion, and sunitinib resistance of RCC cells. Mechanistically, circPTPN12 was found to form a complex with hnRNPM, which was involved in the regulation of mRNA processing. The combination with circPTPN12 enhanced the ability of hnRNPM to maintain the stability of IL-6 mRNA and further activated the STAT3 signaling pathway. The study revealed that circPTPN12/hnRNPM/IL-6/STAT3 axis promoted RCC progression and sunitinib resistance, which might be a promising therapeutic target for relieving sunitinib resistance in RCC.
引用
收藏
页数：13
相关论文
共 50 条
  • [31] IL-6 signaling via the STAT3/SOCS3 pathway: Functional Analysis of the Conserved STAT3 N-domain
    Ling Zhang
    Donna B. Badgwell
    Jack J. Bevers
    Karni Schlessinger
    Peter J. Murray
    David E. Levy
    Stephanie S. Watowich
    Molecular and Cellular Biochemistry, 2006, 288 : 179 - 189
  • [32] Aspirin promotes apoptosis in a murine model of colorectal cancer by mechanisms involving downregulation of IL-6–STAT3 signaling pathway
    Yun Tian
    Ying Ye
    Wei Gao
    Hong Chen
    Ting Song
    Daqing Wang
    Xiaoyun Mao
    Changshan Ren
    International Journal of Colorectal Disease, 2011, 26 : 13 - 22
  • [33] The Role of MRE11 in the IL-6/STAT3 Pathway of Lung Cancer Cells
    Wu, Ching-Yuan
    Shu, Li-Hsin
    Liu, Hung-Te
    Cheng, Yu-Ching
    Wu, Yu-Huei
    Wu, Yu-Heng
    CURRENT ISSUES IN MOLECULAR BIOLOGY, 2022, 44 (12) : 6132 - 6144
  • [34] Berberine inhibits gastric cancer development and progression by regulating the JAK2/STAT3 pathway and downregulating IL-6
    Xu, Minmin
    Ren, Li
    Fan, Jinhua
    Huang, Lu
    Zhou, Liming
    Li, Xuegang
    Ye, Xiaoli
    LIFE SCIENCES, 2022, 290
  • [35] Nuclear translocation of thioredoxin-1 promotes colorectal cancer development via modulation of the IL-6/STAT3 signaling axis through interaction with STAT3
    Wu, Aihua
    Fang, Daoquan
    Liu, Yangyang
    Shi, Xiaomeng
    Zhong, Zuyue
    Zhou, Baojian
    Ye, Lechi
    Sun, Xuecheng
    Jiang, Lei
    THERANOSTICS, 2023, 13 (14): : 4730 - 4744
  • [36] IL-6 PROMOTES MYC-INDUCED LYMPHOMAGENESIS INDEPENDENT OF STAT3
    Marshall, N. Reich
    Mena-Taboada, P.
    Poli, V.
    Petrenko, A.
    CYTOKINE, 2016, 87 : 112 - 113
  • [37] Peripheral IL-6/STAT3 signaling promotes beiging of white fat
    Li, Haifang
    Dong, Mei
    Liu, Wenhui
    Gao, Cheng
    Jia, Yanxin
    Zhang, Xinzhi
    Xiao, Xue
    Liu, Qingxin
    Lin, Hai
    BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2021, 1868 (10):
  • [38] The Transcription Factor IRF9 Promotes Colorectal Cancer via Modulating the IL-6/STAT3 Signaling Axis
    Sharma, Bhesh Raj
    Karki, Rajendra
    Sundaram, Balamurugan
    Wang, Yaqiu
    Vogel, Peter
    Kanneganti, Thirumala-Devi
    CANCERS, 2022, 14 (04)
  • [39] Genetic variants in IL-6/JAK/STAT3 pathway and the risk of CRC
    Wang, Shuwei
    Zhang, Weidong
    TUMOR BIOLOGY, 2016, 37 (05) : 6561 - 6569
  • [40] Over Activation of IL-6/STAT3 Signaling Pathway in Juvenile Dermatomyositis
    Zheng, Qi
    Wang, Zhaoling
    Tan, Yejun
    Zhu, Kun
    Lu, Meiping
    RHEUMATOLOGY AND THERAPY, 2024, 11 (05) : 1255 - 1269
12345