Maternal anxiety forecasts shorter prolongation of pregnancies complicated by early-onset preeclampsia

被引:0
作者
van Esch, Joris J. A. [1 ]
Bolte, Antoinette C. [1 ]
Spaanderman, Marc E. A. [1 ]
Vandenbussche, Frank P. H. A. [1 ]
de Weerth, Carolina [2 ]
Beijers, Roseriet [2 ,3 ]
机构
[1] Radboud Univ Nijmegen, Dept Obstet & Gynecol, Med Ctr, Geert Grootepl Zuid 10,Post 623,POB 9101, NL-6500 HB Nijmegen, Netherlands
[2] Radboud Univ Nijmegen, Donders Inst, Dept Cognit Neurosci, Med Ctr, Kapittelweg 29, NL-6525 EN Nijmegen, Netherlands
[3] Radboud Univ Nijmegen, Behav Sci Inst, Dept Dev Psychol, POB 9104, NL-6500 HE Nijmegen, Netherlands
关键词
Early-onset preeclampsia; Stress; Anxiety; Hair cortisol; Pregnancy prolongation; HAIR CORTISOL; CHILD OUTCOMES; STRESS; WOMEN;
D O I
10.1007/s00404-022-06836-2
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Purpose In early-onset preeclampsia, each additional day of pregnancy prolongation reduces offspring infant mortality about 9%. We evaluated if maternal stress at admission to hospital for early-onset preeclampsia predicted admission-to-delivery intervals in days. Methods This prospective, longitudinal cohort-study involved 15 singleton pregnancies with a diagnosis of preeclampsia before 34 weeks gestation with intended expectant management. Upon hospital admission, maternal psychological stress was assessed with questionnaires and physiological stress with hair cortisol. Hair samples were analyzed in three hair segments representing the preconception period, and the first and second trimester of pregnancy. Results Mean pregnancy prolongation was 16.2 days. Higher maternal anxiety at hospital admission significantly correlated with shorter admission-to-delivery intervals (r = - 0.54, p = 0.04). Chronically increased hair cortisol concentrations (i.e. from preconception through the second trimester) of pregnancy tended to be related to shorter admission-to-delivery intervals (p <. 10). Conclusion Higher reported anxiety is, and chronically high hair cortisol tended to be, related with fewer days of prolongation from admission to delivery in women with early-onset preeclampsia. These findings suggest that maternal stress might be a potential determinant of disease progression. Future research into early innovative stress-reducing interventions for early-onset preeclampsia may shed more light on the etiology and treatment of this disease.
引用
收藏
页码:1703 / 1711
页数:9
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