Roles of the miR-155 in Neuroinflammation and Neurological Disorders: A Potent Biological and Therapeutic Target

被引：37

作者：

Rastegar-Moghaddam, Seyed Hamidreza ^{[1
,2
]}

Ebrahimzadeh-Bideskan, Alireza ^{[1
,2
]}

Shahba, Sara ^{[3
]}

Malvandi, Amir Mohammad ^{[4
]}

Mohammadipour, Abbas ^{[1
]}

机构：

[1] Mashhad Univ Med Sci, Sch Med, Dept Anat & Cell Biol, POB 91779-48564, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Appl Biomed Res Ctr, Sch Med, Mashhad, Razavi Khorasan, Iran

[3] Guilan Univ Med Sci, Med Biotechnol Res Ctr, Sch Paramed, Rasht, Iran

[4] IRCCS Ist Ortoped Galeazzi, Lab Expt Biochem & Mol Biol, Via Riccardo Galeazzi 4, I-20161 Milan, Italy

来源：

CELLULAR AND MOLECULAR NEUROBIOLOGY | 2023年 / 43卷 / 02期

关键词：

MicroRNA-155; Neurodegenerative diseases; Epilepsy; Brain malignancies; Stroke; RNA therapeutics; TH17; CELL-DIFFERENTIATION; DOWN-REGULATION; MULTIPLE-SCLEROSIS; ALZHEIMERS-DISEASE; GLIOMA-CELLS; INFLAMMATORY RESPONSE; MIRNA-155; PROMOTES; GENE-EXPRESSION; UP-REGULATION; IN-VIVO;

D O I：

10.1007/s10571-022-01200-z

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Neuroinflammation plays a crucial role in the development and progression of neurological disorders. MicroRNA-155 (miR-155), a miR is known to play in inflammatory responses, is associated with susceptibility to inflammatory neurological disorders and neurodegeneration, including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis as well as epilepsy, stroke, and brain malignancies. MiR-155 damages the central nervous system (CNS) by enhancing the expression of pro-inflammatory cytokines, like IL-1 beta, IL-6, TNF-alpha, and IRF3. It also disturbs the blood-brain barrier by decreasing junctional complex molecules such as claudin-1, annexin-2, syntenin-1, and dedicator of cytokinesis 1 (DOCK-1), a hallmark of many neurological disorders. This review discusses the molecular pathways which involve miR-155 as a critical component in the progression of neurological disorders, representing miR-155 as a viable therapeutic target.

引用

页码：455 / 467

页数：13

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