Postoperative Coagulation Changes in Patients after Epicardial Left Atrial Appendage Occlusion Varies Based on the Left Atrial Appendage Size

被引：4

作者：

Batko, Jakub ^{[1
,2
]}

Rusinek, Jakub ^{[1
]}

Slomka, Artur ^{[2
,3
]}

Litwinowicz, Radoslaw ^{[1
,4
]}

Burysz, Marian ^{[4
]}

Bartus, Magdalena ^{[5
]}

Lakkireddy, Dhanunjaya R. ^{[6
]}

Lee, Randall J. ^{[7
,8
]}

Natorska, Joanna ^{[9
]}

Zabczyk, Michal ^{[9
]}

Kapelak, Boguslaw ^{[10
]}

Bartus, Krzysztof ^{[10
]}

机构：

[1] Jagiellonian Univ Med Coll, Inst Cardiol, Dept Cardiovasc Surg & Transplantol, CAROL Cardiothorac Anat Res Operat Lab, PL-31008 Krakow, Poland

[2] Coll Medicum Nicolaus Copernicus Univ, Thorac Res Ctr, Innovat Med Forum, PL-85094 Bydgoszcz, Poland

[3] Nicolaus Copernicus Univ Torun, Dept Pathophysiol, Ludwik Rydygier Coll Medicum Bydgoszcz, PL-85094 Bydgoszcz, Poland

[4] Reg Specialist Hosp, Dept Cardiac Surg, PL-86300 Grudziadz, Poland

[5] Jagiellonian Univ Med Coll, Dept Pharmacol, PL-31008 Krakow, Poland

[6] HCA MIDWEST HLTH, Kansas City Heart Rhythm Inst & Res Fdn, Second Floor, 5100 110th St, Overland Pk, KS 66211 USA

[7] Univ Calif San Francisco, Dept Med, San Francisco, CA 94158 USA

[8] Univ Calif San Francisco, Cardiovasc Res Inst, San Francisco, CA 94158 USA

[9] Jagiellonian Univ Med Coll, Inst Cardiol, Inst Cardiol, PL-31008 Krakow, Poland

[10] Jagiellonian Univ Med Coll, Inst Cardiol, Dept Cardiovasc Surg & Transplantol, PL-31008 Krakow, Poland

来源：

DISEASES | 2024年 / 12卷 / 01期

关键词：

left atrial appendage; atrial fibrillation; left atrial appendage occlusion; LARIAT; coagulation; thrombolysis; left atrial appendage anatomy; coagulation factors; PLASMINOGEN-ACTIVATOR INHIBITOR-1; FIBRILLATION; RISK; CLOSURE; STROKE;

D O I：

10.3390/diseases12010008

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Left atrial appendage occlusion affects systemic coagulation parameters, leading to additional patient-related benefits. The aim of this study was to investigate the differences in coagulation factor changes 6 months after epicardial left atrial appendage occlusion in patients with different LAA morphometries. This is the first study to analyze these relationships in detail. A prospective study of 22 consecutive patients was performed. Plasminogen, fibrinogen, tPA concentration, PAI-1, TAFI and computed tomography angiograms were performed. Patients were divided into subgroups based on left atrial appendage body and orifice diameter enlargement. The results of blood tests at baseline and six-month follow-up were compared. In a population with normal LAA body size and normal orifice diameter size, a significant decrease in analyzed clotting factors was observed between baseline and follow-up for all parameters except plasminogen. A significant decrease between baseline and follow-up was observed with enlarged LAA body size in all parameters except TAFI, in which it was insignificant and plasminogen, in which a significant increase was observed. Occlusion of the left atrial appendage is beneficial for systemic coagulation. Patients with a small LAA may benefit more from LAA closure in terms of stabilizing their coagulation factors associated with potential thromboembolic events in the future.

引用

页数：13

共 40 条

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