Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers

被引：1
|
作者：
Gorshkova, Marina Yu. [1 ]
Vanchugova, Ludmila V. [1 ]
Volkova, Irina F. [1 ]
Obydennova, Irina, V [1 ]
Valuev, Ivan L. [1 ]
Valuev, Lev I. [1 ]
机构：
[1] Russian Acad Sci, AV Topchiev Inst Petrochem Synth, Moscow 119991, Russia
来源：
MENDELEEV COMMUNICATIONS | 2023年 / 33卷 / 06期
关键词：
two-component hydrogels; interpenetrating networks; poly( N; N -diethylacrylamide); unsaturated derivatives; sodium alginate; covalent network; ionic network; thermosensitive hydrogel; drug delivery system; SODIUM ALGINATE; RELEASE; PH;
D O I：
10.1016/j.mencom.2023.10.020
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
New thermosensitive mucoadhesive hydrogels based on a sodium alginate unsaturated derivative have been synthesized by copolymerization with N,N-diethylacrylamide (DEAAm) in the presence of a crosslinking agent. The formation of covalent bonds between the co-monomers has been shown to cause a significant change in the hydrogel supramolecular structure and makes it possible to regulate the lower critical solution temperature (LCST) of the gels. The possibility of using the hydrogels as drug carriers with a temperature-controlled drug release rate has been demonstrated in experiments in vitro.
引用
收藏
页码：799 / 801
页数：3
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