Thermosensitive and mucoadhesive hydrogels based on modified alginate as drug carriers

New thermosensitive mucoadhesive hydrogels based on a sodium alginate unsaturated derivative have been synthesized by copolymerization with N,N-diethylacrylamide (DEAAm) in the presence of a crosslinking agent. The formation of covalent bonds between the co-monomers has been shown to cause a significant change in the hydrogel supramolecular structure and makes it possible to regulate the lower critical solution temperature (LCST) of the gels. The possibility of using the hydrogels as drug carriers with a temperature-controlled drug release rate has been demonstrated in experiments in vitro.