Successful autologous stem cell transplantation for light chain proximal tubulopathy with severe kidney injury

被引：1

作者：

Kono, Asuka ^{[1
,2
]}

Bando, Kana ^{[1
]}

Takahata, Atsushi ^{[1
]}

Toyota, Shigeo ^{[1
]}

机构：

[1] Yokosuka Kyosai Hosp, Dept Hematol, Yokosuka, Japan

[2] 1-16 Yonegahama Doori, Yokosuka, Kanagawa 2388558, Japan

来源：

CLINICAL CASE REPORTS | 2023年 / 11卷 / 12期

关键词：

Fanconi syndrome; hematopoietic stem cell transplantation; monoclonal Gammopathy of undetermined significance; multiple myeloma; proximal renal tubular dysfunction; ACQUIRED FANCONI-SYNDROME; PATIENT; SERIES;

D O I：

10.1002/ccr3.8337

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Light chain proximal tubulopathy (LCPT) is a rare type of monoclonal gammopathy of renal significance. Clinicians should consider LCPT in the differential diagnosis of patients with renal or proximal tubular dysfunction with monoclonal gammopathy. They should confirm diagnosis by renal biopsy and initiate chemotherapy before disease progression. Renal biopsy findings. Light microscopic photomicrographs of glomeruli and proximal tubules. Hematoxylin and eosin staining image (A, x200) shows no remarkable abnormalities. Immunofluorescence staining image of kappa light chain in proximal tubular epithelial cells (B, x400). Electron microscopic image of proximal tubules (C) shows rhomboid crystal deposition in the proximal tubular epithelial cells.image

引用

页数：8

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