Iridium-Catalyzed Cascade Reaction of Sulfoxonium Ylides with o-Aminoaryl Aldehydes for the Synthesis of 2-Acylindoles

被引：0

作者：

Tong, Yixin ^{[1
]}

Mi, E. ^{[1
]}

Zhou, Li ^{[1
]}

Wang, Xiabin ^{[1
]}

Xiong, Biao ^{[1
]}

机构：

[1] Nantong Univ, Sch Pharm, 19 Qixiu Rd, Nantong 226001, Jiangsu, Peoples R China

来源：

CHEMISTRYSELECT | 2023年 / 8卷 / 40期

基金：

中国国家自然科学基金;

关键词：

2-Acylindoles; Sulfoxonium ylides; Iridium-; catalyzed; N-H Insertion; Annulation; 2-SUBSTITUTED INDOLES; BIOLOGICAL EVALUATION; SULFUR YLIDES; DERIVATIVES; ANNULATION; CYCLOADDITION; ACTIVATION; PYRROLES; POTENT;

D O I：

10.1002/slct.202303078

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

2-Acylindoles possess widespread applications in functional chemicals. However, the convenient and selective synthesis of such important substructures has to date remained a challenge. Herein, a method to achieve 2-acylindoles from sulfoxonium ylides with o-aminoaryl aldehydes catalysed by Iridium has been developed with the merits of broad substrate scope, good functional tolerance, high efficiency and operational simplicity, which provides an alternative way to access functionalized indoles.

引用

页数：5

共 69 条

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