Advances in synthesis and biological activities of quinazoline scaffold analogues: A review

Creating effective, ecologically friendly, and commercially viable synthetic routes is crucial in the design and synthesis of organic substances. Quinazoline, a heterocyclic compound with nitrogen, is one of the most significant heterocyclic motifs with diverse chemical reactivities and many biological applications. Its derivatives comprise a family of fused heterocycles in over 200 naturally occurring alkaloids. Over the past few decades, newer, more complex drugs containing quinazolinone structures have been discovered, with enormous progress in designing various efficient protocols to construct these pharmacologically active scaffolds. This review evaluated the recently investigated protocols for synthesizing quinazolines and their derivatives (from 2017 to 2023 till date). The current review paper provides an up-to-date description of recent advancements in straightforward synthetic procedures that result in the creation of quinazoline molecules. In addition, the significant therapeutical activities of numerous quinazoline-based drugs were briefed and assessed in this review. We envisage that this information would assist researchers in designing and synthesizing novel quinazoline analogues as lead compounds. & COPY; 2023 The Author(s). Published by Elsevier B.V. on behalf of King Saud University. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).