Research progress on drug delivery systems for curcumin in the treatment of gastrointestinal tumors

被引：5
作者：
Wu, Xin [1 ]
Yang, Yang [2 ]
机构：
[1] Harbin Med Univ Canc Hosp, Dept Pharm, Harbin 150081, Heilongjiang, Peoples R China
[2] Harbin Med Univ Canc Hosp, Dept Resp Oncol, 150 Haping Rd, Harbin 150081, Heilongjiang, Peoples R China
来源：
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY | 2023年 / 15卷 / 08期
关键词：
Curcumin; Digestive tract tumors; Delivery system; Water-soluble; Solubility; NANOPARTICLES; METASTASIS;
D O I：
10.4251/wjgo.v15.i8.1342
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Curcumin is a natural compound with a diketone structure, which can control the growth, metastasis, recurrence, neovascularization, invasion, and drug resistance of gastrointestinal tumors by inhibiting nuclear factor ?B, overexpression of tumor cells, vascular endothelial growth factor, etc. However, due to the low bioavailability of curcumin formulation, it did not fully exert its pharmacological effects, and its application and development in the treatment of various malignant tumors are still limited. This review summarizes the research on drug delivery systems of curcumin combating digestive tract tumors in order to further reduce the toxic side effects of curcumin-containing drugs and fully exert their pharmacological activities, and improve their bioavailability and clinical value.
引用
收藏
页码：1342 / 1348
页数：7
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