Tryptophan metabolism in health and disease

被引：410

作者：

Xue, Chen ^{[1
]}

Li, Ganglei ^{[2
]}

Zheng, Qiuxian ^{[1
]}

Gu, Xinyu ^{[1
]}

Shi, Qingmiao ^{[1
]}

Su, Yuanshuai ^{[1
]}

Chu, Qingfei ^{[1
]}

Yuan, Xin ^{[1
]}

Bao, Zhengyi ^{[1
]}

Lu, Juan ^{[1
]}

Li, Lanjuan ^{[1
]}

机构：

[1] Zhejiang Univ, State Key Lab Diag & Treatment Infect Dis, Collaborat Innovat Ctr Diag & Treatment Infect Dis, Natl Clin Res Ctr Infect Dis,Affiliated Hosp 1,Sch, Hangzhou 310003, Peoples R China

[2] Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Neurosurg, Hangzhou 310003, Peoples R China

来源：

CELL METABOLISM | 2023年 / 35卷 / 08期

关键词：

ARYL-HYDROCARBON RECEPTOR; INDOLEAMINE 2,3-DIOXYGENASE EXPRESSION; IRRITABLE-BOWEL-SYNDROME; QUINOLINIC ACID; KYNURENINE PATHWAY; GUT MICROBIOTA; IDO EXPRESSION; SEROTONIN SYNTHESIS; ANOIKIS RESISTANCE; CELL-PROLIFERATION;

D O I：

10.1016/j.cmet.2023.06.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and indole pathways. A variety of bioactive compounds produced via Trp metabolism can regulate various physiological functions, including inflammation, metabolism, immune responses, and neurological function. Emerging evidence sup-ports an intimate relationship between Trp metabolism disorder and diseases. The levels or ratios of Trp metabolites are significantly associated with many clinical features. Additionally, studies have shown that disease progression can be controlled by modulating Trp metabolism. Indoleamine-2,3-dioxygenase, Trp-2,3-dioxygenase, kynurenine-3-monooxygenase, and Trp hydroxylase are the rate-limiting enzymes that are critical for Trp metabolism. These key regulatory enzymes can be targeted for treating several dis-eases, including tumors. These findings provide novel insights into the treatment of diseases. In this review, we have summarized the recent research progress on the role of Trp metabolites in health and disease along with their clinical applications.

引用

页码：1304 / 1326

页数：23

共 191 条

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