The Future of Precision Oncology

被引：28

作者：

Rulten, Stuart L. ^{[1
]}

Grose, Richard P. ^{[2
]}

Gatz, Susanne A. ^{[3
]}

Jones, J. Louise ^{[2
]}

Cameron, Angus J. M. ^{[2
]}

机构：

[1] Prime Global, Prime Om, Knutsford WA16, England

[2] Queen Mary Univ London, Barts Canc Inst, Ctr Tumour Biol, London EC1M 6BQ, England

[3] Univ Birmingham, Inst Canc & Genom Sci, Canc Res UK Clin Trials Unit CRCTU, Birmingham B15 2TT, W Midlands, England

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023年 / 24卷 / 16期

关键词：

precision oncology; molecular profiling; genomics; transcriptomics; proteomics; microbiome; metabolomics; MUTATIONAL LANDSCAPE; SEQUENCE VARIANTS; BREAST-CANCER; YOUNG-ADULTS; TUMORS; THERAPY; TRIAL; IMMUNOTHERAPY; CHEMOTHERAPY; CONCORDANCE;

D O I：

10.3390/ijms241612613

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Our understanding of the molecular mechanisms underlying cancer development and evolution have evolved rapidly over recent years, and the variation from one patient to another is now widely recognized. Consequently, one-size-fits-all approaches to the treatment of cancer have been superseded by precision medicines that target specific disease characteristics, promising maximum clinical efficacy, minimal safety concerns, and reduced economic burden. While precision oncology has been very successful in the treatment of some tumors with specific characteristics, a large number of patients do not yet have access to precision medicines for their disease. The success of next-generation precision oncology depends on the discovery of new actionable disease characteristics, rapid, accurate, and comprehensive diagnosis of complex phenotypes within each patient, novel clinical trial designs with improved response rates, and worldwide access to novel targeted anticancer therapies for all patients. This review outlines some of the current technological trends, and highlights some of the complex multidisciplinary efforts that are underway to ensure that many more patients with cancer will be able to benefit from precision oncology in the near future.

引用

页数：18

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