Health risk assessment of exposure to triclosan in pregnant women using Monte Carlo simulation techniques: based on biomonitoring data

被引：3

作者：

Attarian, Elham ^{[1
,2
]}

Mohammadi, Farzaneh ^{[2
,3
]}

Ebrahimpour, Karim ^{[2
,3
]}

Moazeni, Malihe ^{[1
,2
]}

Maracy, Mohammadreza ^{[3
,4
]}

Ebrahimi, Afshin ^{[2
,3
]}

Kelishadi, Roya ^{[5
]}

机构：

[1] Isfahan Univ Med Sci, Student Res Comm, Sch Hlth, Esfahan, Iran

[2] Isfahan Univ Med Sci, Sch Hlth, Dept Environm Hlth Engn, Esfahan, Iran

[3] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Environm Res Ctr, Esfahan, Iran

[4] Isfahan Univ Med Sci, Sch Hlth, Dept Epidemiol & Biostat, Esfahan, Iran

[5] Isfahan Univ Med Sci, Res Inst Primordial Prevent Noncommunicable Dis, Child Growth & Dev Res Ctr, Dept Pediat, Esfahan, Iran

来源：

JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART C-TOXICOLOGY AND CARCINOGENESIS | 2023年 / 41卷 / 1-2期

关键词：

Triclosan; pregnant women; risk assessment; Monte Carlo method; pharmaceutical preparations; URINARY CONCENTRATIONS; DRINKING-WATER; ASSOCIATION; POPULATION; PREDICTORS; SURFACE; SAMPLES; CHINA;

D O I：

10.1080/26896583.2023.2226587

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This study aimed to assess the triclosan (TCS) health risk in an Iranian pregnant women sample by Monte Carlo simulation (MCS). The urinary TCS of 99 women after the 28(th) week of pregnancy was detected by gas chromatography/mass spectrometry detector (GC/MS), and the MCS model implemented a health risk assessment. The corresponding hazard quotient (HQ) and the sensitivity analysis were calculated. TCS was measured in 100% of the urine samples with a median concentration of 2.89 & mu;g/L. The median of HQ was obtained at 1.93 x 10(-4). The TCS exposure risk in the studied population was lower than the allowable limit. A comparison between HQ values in the two weight subgroups of pregnant women showed that the risk level is almost equal, and there was minimal health risk in pregnant women from exposure to TCS.

引用

收藏

页码：61 / 75

页数：15

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