Diverticular Disease and Rifaximin: An Evidence-Based Review

被引：10

作者：

Piccin, Anna ^{[1
]}

Gulotta, Marco ^{[1
]}

di Bella, Stefano ^{[1
,2
]}

Martingano, Paola ^{[3
]}

Croce, Lory Saveria ^{[1
,4
]}

Giuffre, Mauro ^{[1
,5
]}

机构：

[1] Univ Trieste, Dept Med Surg & Hlth Sci, I-34149 Trieste, Italy

[2] Azienda Sanit Univ Giuliano Isontina ASUGI, Infect Dis Dept, I-34128 Trieste, Italy

[3] Azienda Sanit Univ Giuliano Isontina ASUGI, Dept Radiol, I-34128 Trieste, Italy

[4] Azienda Sanit Univ Giuliano Isontina ASUGI, Liver Clin, I-34128 Trieste, Italy

[5] Yale Univ, Yale Sch Med, Dept Internal Med, New Haven, CT 06510 USA

来源：

ANTIBIOTICS-BASEL | 2023年 / 12卷 / 03期

关键词：

diverticulosis; diverticular disease; acute diverticulitis; rifaximin; fiber supplementation; microbiota; diverticular bleeding; diverticulitis prevention; diverticulitis prophylaxis; ACUTE COLONIC DIVERTICULITIS; C-REACTIVE PROTEIN; RANDOMIZED CLINICAL-TRIAL; IN-VITRO ACTIVITY; IRRITABLE-BOWEL-SYNDROME; DOUBLE-BLIND; CLOSTRIDIUM-DIFFICILE; PRACTICE PARAMETERS; ITALIAN SOCIETY; GUT MICROBIOTA;

D O I：

10.3390/antibiotics12030443

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

There have been considerable advances in the treatment of diverticular disease in recent years. Antibiotics are frequently used to treat symptoms and prevent complications. Rifaximin, a non-absorbable antibiotic, is a common therapeutic choice for symptomatic diverticular disease in various countries, including Italy. Because of its low systemic absorption and high concentration in stools, it is an excellent medicine for targeting the gastrointestinal tract, where it has a beneficial effect in addition to its antibacterial properties. Current evidence shows that cyclical rifaximin usage in conjunction with a high-fiber diet is safe and effective for treating symptomatic uncomplicated diverticular disease, while the cost-effectiveness of long-term treatment is unknown. The use of rifaximin to prevent recurrent diverticulitis is promising, but further studies are needed to confirm its therapeutic benefit. Unfortunately, there is no available evidence on the efficacy of rifaximin treatment for acute uncomplicated diverticulitis.

引用

页数：17

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