Alkanes in Minisci-Type Reaction under Photocatalytic Conditions with Hydrogen Evolution

被引：23
|
作者：
Laze, Loris [1 ,2 ]
Quevedo-Flores, Beatriz [1 ,2 ]
Bosque, Irene [1 ,2 ]
Gonzalez-Gomez, Jose C. [1 ,2 ]
机构：
[1] Univ Alicante, Inst Sintesis Organ ISO, Alacant 03080, Spain
[2] Univ Alicante, Dept Quim Organ, Alacant 03080, Spain
来源：
ORGANIC LETTERS | 2023年 / 25卷 / 48期
关键词：
FUNCTIONALIZATION; HETEROARENES;
D O I：
10.1021/acs.orglett.3c02619
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
We report herein a protocol for the selective activation of C-(sp 3)-H bonds based on the interplay of two readily available organic catalysts and their successful implementation in cross-coupling azaarenes with alkanes. This Minisci-like reaction is promoted by visible light at room temperature and is free from chemical oxidants, metals, and chlorinated solvents. A wide range of substrates are compatible, including some bioactive molecules. Mechanistic studies support a dual catalytic cycle with H-2 evolution.
引用
收藏
页码：8541 / 8546
页数：6
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