Transcranial Alternating Current Stimulation in a Patient with Ataxia-Ocular Apraxia 2: a Case Report

被引：0
作者：
Cheng, Xiao-Ping [1 ]
Yu, Wen-Hui [2 ]
Liu, Xia [1 ]
Lin, Wei [3 ,4 ,5 ]
Wang, Zhao-Di [6 ]
Wang, Xi-Chen [1 ]
Ni, Jun [1 ]
Cai, Nai-Qing [3 ,4 ,5 ]
Chen, Xin-Yuan [1 ,7 ]
机构：
[1] Fujian Med Univ, Affiliated Hosp 1, Dept Rehabil Med, Fuzhou 350005, Peoples R China
[2] Fujian Med Univ, Sch Hlth, Fuzhou 350122, Peoples R China
[3] Fujian Med Univ, Dept Neurol, Fuzhou 350005, Peoples R China
[4] Fujian Med Univ, Inst Neurol, Inst Neurosci, Affiliated Hosp 1, Fuzhou 350005, Peoples R China
[5] Fujian Med Univ, Fujian Key Lab Mol Neurol, Fuzhou 350005, Peoples R China
[6] Nanjing Med Univ, Dept Rehabil Med, Affiliated Suzhou Hosp, Suzhou 215008, Peoples R China
[7] Fujian Med Univ, Affiliated Hosp 1, Natl Reg Med Ctr, Dept Rehabil Med, Binhai Campus, Fuzhou 350212, Peoples R China
来源：
CEREBELLUM | 2024年 / 23卷 / 04期
关键词：
Ataxia-ocular apraxia 2; <middle dot> Transcranial alternating current stimulation; <middle dot> International Cooperative Ataxia Rating Scale; <middle dot> The Scale for the Assessment and Rating of Ataxia; <middle dot> The 9-Hole Peg Test; <middle dot> Functional near-infrared spectroscopy;
D O I：
10.1007/s12311-023-01637-y
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Ataxia-ocular apraxia 2 (AOA2) is a rare neurodegenerative autosomal recessive disorder with no effective treatment. In this study, we present the case of a patient diagnosed with AOA2, who experienced walking instability and uncoordinated movement. The patient underwent transcranial alternating current stimulation (tACS) treatment for 4 weeks with follow-up after 1 month. The effectiveness of the treatment was evaluated using the International Cooperative Ataxia Rating Scale (ICARS), the Scale for the Assessment and Rating of Ataxia (SARA), the 9-Hole Peg Test (9HPT), and functional near-infrared spectroscopy (fNIRS). Following treatment, the patient's ataxia symptoms showed significant improvement and continued to be alleviated during the follow-up period, suggesting a lasting effect of tACS treatment. Our findings from this case study provide compelling evidence for the potential of tACS as a treatment option for AOA2.
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收藏
页码：1713 / 1717
页数：5
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