Current insights in the preclinical study of palatal wound healing and oronasal fistula after cleft palate repair

被引：0

作者：

Chen, Jiali ^{[1
,2
]}

Yang, Renjie ^{[2
,3
]}

Yin, Jiayi ^{[1
,2
]}

Shi, Bing ^{[1
,2
]}

Huang, Hanyao ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Hosp Stomatol, Dept Oral & Maxillofacial Surg, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[2] Sichuan Univ, West China Hosp Stomatol, Natl Clin Res Ctr Oral Dis, Chengdu, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

基金：

中国国家自然科学基金;

关键词：

mechanism; oronasal fistula; oral microflora; treatments; wound healing; ACELLULAR DERMAL MATRIX; PLATELET-RICH FIBRIN; ORTHODONTIC TOOTH MOVEMENT; ELECTRICAL-STIMULATION; AMNIOTIC MEMBRANE; STEM-CELL; CLOSURE; LIP; CHILDREN; DEFECTS;

D O I：

10.3389/fcell.2023.1271014

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Poor palatal wound healing after cleft palate repair could lead to unfavorable prognosis such as oronasal fistula (ONF), which might affect the patient's velopharyngeal function as well as their quality of life. Thus, restoring poor palatal wound healing for avoiding the occurrence of ONF should be considered the key to postoperative care after cleft palate repair. This review provided current insights in the preclinical study of poor palatal wound healing after cleft palate repair. This review comprehensively introduced the animal model establishment for palatal wound healing and related ONF, including the models by mice, rats, piglets, and dogs, and then demonstrated the aspects for investigating poor palatal wound healing and related treatments, including possible signaling pathways that could be involved in the formation of poor palatal wound healing, the related microbiota changes because of the deformity of palatal structure, and the studies for potential therapeutic strategies for palatal wound healing and ONF. The purpose of this review was to show the state of the art in preclinical studies about palatal wound healing after cleft palate repair and to show the promising aspects for better management of palatal wound healing.

引用

页数：8