Metabolomics and Self-Reported Depression, Anxiety, and Phobic Symptoms in the VA Normative Aging Study

被引:1
作者
Prince, Nicole [1 ,2 ]
Stav, Meryl [1 ]
Cote, Margaret [1 ]
Chu, Su H. [1 ,2 ]
Vyas, Chirag M. [2 ,3 ]
Okereke, Olivia I. [1 ,2 ,3 ,4 ]
Palacios, Natalia [4 ,5 ,6 ]
Litonjua, Augusto A. [7 ]
Vokonas, Pantel [8 ,9 ]
Sparrow, David [8 ,9 ,10 ]
Spiro, Avron, III [9 ,10 ,11 ,12 ]
Lasky-Su, Jessica A. [1 ,2 ]
Kelly, Rachel S. [1 ,2 ]
机构
[1] Brigham & Womens Hosp, Channing Div Network Med, Boston, MA 02115 USA
[2] Harvard Med Sch, Boston, MA 02115 USA
[3] Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USA
[4] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[5] Univ Massachusetts Lowell, Zuckerberg Coll Hlth Sci, Dept Publ Hlth, Lowell, MA 01854 USA
[6] Edith Nourse Rogers Mem Vet Hosp, Geriatr Res Educ Clin Ctr, Bedford, MA 01730 USA
[7] Univ Rochester, Golisano Childrens Hosp Strong, Div Pediat Pulm Med, Med Ctr, Rochester, NY 14642 USA
[8] Dept Vet Affairs, Boston, MA 02114 USA
[9] VA Boston Healthcare Syst, VA Normat Aging Study, Boston, MA 02130 USA
[10] Boston Univ, Chobanian & Avidisian Sch Med, Dept Med, Boston, MA 02118 USA
[11] Boston Univ, Dept Epidemiol, Sch Publ Hlth, Boston, MA 02118 USA
[12] Boston Univ, Chobanian & Avidisian Sch Med, Dept Psychiat, Boston, MA 02118 USA
关键词
metabolomics; normative aging study (NAS); brief symptom inventory (BSI); depression; anxiety; phobic anxiety; mental health; veterans; MENTAL-HEALTH; PSYCHIATRIC-DISORDERS; BLOOD LEAD; IDENTIFICATION; IMPACT; RISK; BONE;
D O I
10.3390/metabo13070851
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Traditional approaches to understanding metabolomics in mental illness have focused on investigating a single disorder or comparisons between diagnoses, but a growing body of evidence suggests substantial mechanistic overlap in mental disorders that could be reflected by the metabolome. In this study, we investigated associations between global plasma metabolites and abnormal scores on the depression, anxiety, and phobic anxiety subscales of the Brief Symptom Inventory (BSI) among 405 older males who participated in the Normative Aging Study (NAS). Our analysis revealed overlapping and distinct metabolites associated with each mental health dimension subscale and four metabolites belonging to xenobiotic, carbohydrate, and amino acid classes that were consistently associated across all three symptom dimension subscales. Furthermore, three of these four metabolites demonstrated a higher degree of alteration in men who reported poor scores in all three dimensions compared to men with poor scores in only one, suggesting the potential for shared underlying biology but a differing degree of perturbation when depression and anxiety symptoms co-occur. Our findings implicate pathways of interest relevant to the overlap of mental health conditions in aging veterans and could represent clinically translatable targets underlying poor mental health in this high-risk population.
引用
收藏
页数:14
相关论文
共 50 条
  • [11] Self-reported depression and anxiety symptoms in school-aged Singaporean children
    Magiati, Iliana
    Ponniah, Kathryn
    Ooi, Yoon Phaik
    Chan, Yiong Huak
    Fung, Daniel
    Woo, Bernardine
    ASIA-PACIFIC PSYCHIATRY, 2015, 7 (01) : 91 - 104
  • [12] Gender differences in self-reported symptoms of depression and anxiety in adults with intellectual disabilities
    Chester, Rebecca
    Chaplin, Eddie
    Tsakanikos, Elias
    McCarthy, Jane
    Bouras, Nick
    Craig, Tom
    ADVANCES IN MENTAL HEALTH AND INTELLECTUAL DISABILITIES, 2013, 7 (04) : 191 - 200
  • [13] Exploring the Prevalence and Factors Influencing Clinical Trial Awareness in US Adults with Self-Reported Depression and Anxiety
    Sanusi, Ibilola A.
    Arisoyin, Abimbola E.
    Aruoture, Shaw
    Folorunsho, Ibrahim L.
    Okereke, Obiamaka P.
    Adeyemo, Damilola A.
    Salawu, Mujeeb A.
    Okobi, Okelue E.
    Gupta, Akash
    Akunne, Henrietta S.
    Patel, Radhey
    Emmanuel, Omotola
    Ezeudemba, Nneka C.
    CUREUS JOURNAL OF MEDICAL SCIENCE, 2023, 15 (06)
  • [14] A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol
    Casteleijn, David
    Steel, Amie
    Bowman, Diana
    Lauch, Romy
    Wardle, Jon
    INTEGRATIVE MEDICINE RESEARCH, 2019, 8 (02) : 123 - 128
  • [15] Self-reported attachment style, attachment quality, and symptoms of anxiety and depression in young adolescents
    Muris, P
    Meesters, C
    van Melick, M
    Zwambag, L
    PERSONALITY AND INDIVIDUAL DIFFERENCES, 2001, 30 (05) : 809 - 818
  • [16] Examining longitudinal associations between self-reported depression, anxiety and stress symptoms and hair cortisol among mothers of young children
    Bryson, Hannah
    Middleton, Melissa
    Huque, Hamidul
    Mensah, Fiona
    Goldfeld, Sharon
    Price, Anna M. H.
    JOURNAL OF AFFECTIVE DISORDERS, 2021, 282 : 921 - 929
  • [17] Online guided meditation training (Isha Kriya) improves self-reported symptoms of anxiety and depression within 2 weeks of practice-An observational study
    Hariri, Sepideh
    Vishnubhotla, Ramana V.
    Reed, Preeti Upadhyay
    Rayapuraju, Akila
    Orui, Hibiki
    Balachundhar, Pavitra
    Sadhasivam, Senthilkumar
    Subramaniam, Balachundhar
    FRONTIERS IN PSYCHIATRY, 2022, 13
  • [18] A Comparison of Self-Reported Anxiety and Depression Among Undergraduate Music Majors and Nonmusic Majors
    Gilbert, Danni
    JOURNAL OF MUSIC TEACHER EDUCATION, 2021, 30 (03) : 69 - 83
  • [19] The relationship of anxiety and depression with self-reported knee pain in the community: Data from the Baltimore Longitudinal Study of Aging
    Creamer, P
    Lethbridge-Cejku, M
    Costa, P
    Tobin, JD
    Herbst, JH
    Hochberg, MC
    ARTHRITIS CARE & RESEARCH, 1999, 12 (01) : 3 - 7
  • [20] Early Neurodevelopment and Self-Reported Adolescent Symptoms of Depression and Anxiety in a National Canadian Cohort Study
    North, C. Rebecca
    Wild, T. Cam
    Zwaigenbaum, Lonnie
    Colman, Ian
    PLOS ONE, 2013, 8 (02):