Temporal trends in mortality in patients with rheumatoid arthritis: a Danish population-based matched cohort study

被引:5
作者
Soussi, Bolette G. [1 ,2 ,7 ]
Duch, Kirsten [1 ]
Cordtz, Rene L. [1 ]
Lindhardsen, Jesper [3 ]
Kristensen, Salome [1 ,4 ]
Bork, Christian S. [5 ]
Linauskas, Asta [4 ,6 ]
Schmidt, Erik B. [5 ]
Dreyer, Lene [1 ,4 ]
机构
[1] Aalborg Univ Hosp, Ctr Rheumat Res Aalborg, Dept Rheumatol, Aalborg, Denmark
[2] Aalborg Univ Hosp, Clin Canc Res Ctr, Aalborg, Denmark
[3] Rigshospitalet, Ctr Rheumatol & Spine Dis, Lupus & Vasculitis Clin, Copenhagen, Denmark
[4] Aalborg Univ, Dept Clin Med, Aalborg, Denmark
[5] Aalborg Univ Hosp, Dept Cardiol, Aalborg, Denmark
[6] North Denmark Reg Hosp, Dept Rheumatol, Hjorring, Denmark
[7] Aalborg Univ Hosp, Ctr Rheumat Res Aalborg CERRA, Dept Rheumatol, Reberbansgade 15, DK-9000 Aalborg, Denmark
关键词
RA; epidemiology; pseudo-observation; mortality; prognosis; outcome; EXCESS MORTALITY; SURVIVAL; PREVALENCE;
D O I
10.1093/rheumatology/kead325
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives To investigate the 5-year all-cause mortality in patients with RA compared with the general population. Methods This was a nationwide population-based matched cohort study. RA patients diagnosed between 1996 and the end of 2015 were identified using administrative heath registries and followed until the end of 2020 allowing 5 years of follow-up. Patients with incident RA were matched 1:5 on year of birth and sex with non-RA individuals from the Danish general population. Time-to-event analyses were performed using the pseudo-observation approach. Results Compared with matched controls in 1996-2000, the risk difference for RA patients ranged from 3.5% (95% CI 2.7%, 4.4%) in 1996-2000 to -1.6% (95% CI -2.3%, -1.0%) in 2011-15, and the relative risk from 1.3 (95% CI 1.2, 1.4) in 1996-2000 to 0.9 (95% CI 0.8, 0.9) in 2011-15. The age-adjusted 5-year cumulative incidence proportion of death for a 60-year-old RA patient decreased from 8.1% (95% CI 7.3%, 8.9%) when diagnosed in 1996-2000 to 2.9% (95% CI 2.3%, 3.5%) in 2011-15, and for matched controls from 4.6% (95% CI 4.2%, 4.9%) to 2.1% (95% CI 1.9%, 2.4%). Excess mortality persisted in women with RA throughout the study period, while the mortality risk for men with RA in 2011-15 was similar to their matched controls. Conclusions Enhanced improvement in mortality was found in RA patients compared with matched controls, but for sex-specific differences excess mortality was only persistent in women with RA.
引用
收藏
页码:1049 / 1057
页数:9
相关论文
共 27 条
[1]   Rheumatoid arthritis and excess mortality: down but not out. A primary care cohort study using data from Clinical Practice Research Datalink [J].
Abhishek, Abhishek ;
Nakafero, Georgina ;
Kuo, Chang-Fu ;
Mallen, Christian ;
Zhang, Weiya ;
Grainge, Matthew J. ;
Doherty, Michael .
RHEUMATOLOGY, 2018, 57 (06) :977-981
[2]   Pseudo-observations in survival analysis [J].
Andersen, Per Kragh ;
Perme, Maja Pohar .
STATISTICAL METHODS IN MEDICAL RESEARCH, 2010, 19 (01) :71-99
[3]   Regression analysis of restricted mean survival time based on pseudo-observations [J].
Andersen, PK ;
Hansen, MG ;
Klein, JP .
LIFETIME DATA ANALYSIS, 2004, 10 (04) :335-350
[4]   Mortality in rheumatoid arthritis over the last fifty years: Systematic review and meta-analysis [J].
Dadoun, Sabrina ;
Zeboulon-Ktorza, Nadine ;
Combescure, Christophe ;
Elhai, Muriel ;
Rozenberg, Sylvie ;
Gossec, Laure ;
Fautrel, Bruno .
JOINT BONE SPINE, 2013, 80 (01) :29-33
[5]   Survival in rheumatoid arthritis - A population-based analysis of trends over 40 years [J].
Gabriel, SE ;
Crowson, CS ;
Kremers, HM ;
Doran, MF ;
Turesson, C ;
O'Fallon, WM ;
Matteson, EL .
ARTHRITIS AND RHEUMATISM, 2003, 48 (01) :54-58
[6]   The widening mortality gap between rheumatoid arthritis patients and the general population [J].
Gonzalez, Angel ;
Kremers, Hilal Maradit ;
Crowson, Cynthia S. ;
Nicola, Paulo J. ;
Davis, John M., III ;
Therneau, Terry M. ;
Roger, Veronique L. ;
Gabriel, Sherine E. .
ARTHRITIS AND RHEUMATISM, 2007, 56 (11) :3583-3587
[7]  
Harrell FE., 2001, Regression modeling strategies package, DOI 10.1007/978-1-4757-3462-1
[8]   Mortality following new-onset Rheumatoid Arthritis: has modern Rheumatology had an impact? [J].
Holmqvist, Marie ;
Ljung, Lotta ;
Askling, Johan .
ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 (01) :85-91
[9]   Temporal trends in prevalence, incidence, and mortality for rheumatoid arthritis in Quebec, Canada: a population-based study [J].
Jean, Sonia ;
Hudson, Marie ;
Gamache, Philippe ;
Bessette, Louis ;
Fortin, Paul R. ;
Boire, Gilles ;
Bernatsky, Sasha .
CLINICAL RHEUMATOLOGY, 2017, 36 (12) :2667-2671
[10]   All-cause and cause-specific mortality in rheumatoid arthritis, psoriatic arthritis and axial spondyloarthritis: a nationwide registry study [J].
Kerola, Anne M. ;
Kazemi, Amirhossein ;
Rollefstad, Silvia ;
Lillegraven, Siri ;
Sexton, Joseph ;
Wibetoe, Grunde ;
Haavardsholm, Espen A. ;
Kvien, Tore K. ;
Semb, Anne Grete .
RHEUMATOLOGY, 2022, 61 (12) :4656-4666