A biocompatible adenine-based metal-organic framework for Ca2+responsive drug delivery

被引：0

作者：

Jing, Peng ^{[1
]}

Wu, Manni ^{[1
]}

Su, Jia ^{[1
]}

Zhang, Ling ^{[2
]}

Cao, Xianying ^{[3
]}

Jiang, Ke ^{[1
]}

机构：

[1] Hainan Univ, Sch Food Sci & Engn, Key Lab Food Nutr & Funct Food Hainan Prov, Haikou 570228, Peoples R China

[2] Hainan Univ, Sch Mat Sci & Engn, Haikou 570228, Peoples R China

[3] Engn Technol Res Ctr Elderly Hlth Management Haina, Haikou 571137, Peoples R China

来源：

MATERIALS LETTERS | 2023年 / 349卷

基金：

中国国家自然科学基金;

关键词：

Metal-organic framework; Ca 2+responsive drug delivery; Good biocompatibility;

D O I：

10.1016/j.matlet.2023.134812

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

An anionic zinc-adeninate MOF ZJU-64-NH2 has been successfully fabricated by solvothermal method. The high crystallinity of ZJU-64-NH2 was confirmed through powder X-ray diffraction (PXRD) analysis. The cationic model drug procainamide (PA) was efficiently encapsulated into ZJU-64-NH2 through electrostatic interaction, and its loading capacity was determined to be 12.97 wt%. The drug delivery system PA@ZJU-64-NH2 exhibited Ca2+-triggered drug release due to ion exchange, indicating promising potential for bone tumor therapy. The excellent biocompatibility of ZJU-64-NH2 was demonstrated through MTT assay and confocal microscopy imaging.

引用

页数：3

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