A biocompatible adenine-based metal-organic framework for Ca2+responsive drug delivery

被引：0
|
作者：
Jing, Peng [1 ]
Wu, Manni [1 ]
Su, Jia [1 ]
Zhang, Ling [2 ]
Cao, Xianying [3 ]
Jiang, Ke [1 ]
机构：
[1] Hainan Univ, Sch Food Sci & Engn, Key Lab Food Nutr & Funct Food Hainan Prov, Haikou 570228, Peoples R China
[2] Hainan Univ, Sch Mat Sci & Engn, Haikou 570228, Peoples R China
[3] Engn Technol Res Ctr Elderly Hlth Management Haina, Haikou 571137, Peoples R China
来源：
MATERIALS LETTERS | 2023年 / 349卷
基金：
中国国家自然科学基金;
关键词：
Metal-organic framework; Ca 2+responsive drug delivery; Good biocompatibility;
D O I：
10.1016/j.matlet.2023.134812
中图分类号：
T [工业技术];
学科分类号：
08 ;
摘要：
An anionic zinc-adeninate MOF ZJU-64-NH2 has been successfully fabricated by solvothermal method. The high crystallinity of ZJU-64-NH2 was confirmed through powder X-ray diffraction (PXRD) analysis. The cationic model drug procainamide (PA) was efficiently encapsulated into ZJU-64-NH2 through electrostatic interaction, and its loading capacity was determined to be 12.97 wt%. The drug delivery system PA@ZJU-64-NH2 exhibited Ca2+-triggered drug release due to ion exchange, indicating promising potential for bone tumor therapy. The excellent biocompatibility of ZJU-64-NH2 was demonstrated through MTT assay and confocal microscopy imaging.
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页数：3
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