Anticholinergic Drug Burden and Risk of Incident MCI and Dementia A Population-based Study

被引:3
|
作者
Gildengers, Ariel [1 ,7 ]
Stoehr, Gary P. [6 ]
Ran, Xinhui [4 ]
Jacobsen, Erin [1 ]
Teverovsky, Esther [1 ]
Chang, Chung-Chou H. [2 ,4 ]
Ganguli, Mary [1 ,3 ,5 ]
机构
[1] Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA USA
[2] Univ Pittsburgh, Sch Med, Dept Med, Pittsburgh, PA USA
[3] Univ Pittsburgh, Dept Neurol, Sch Med, Pittsburgh, PA USA
[4] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Biostat, Pittsburgh, PA USA
[5] Univ Pittsburgh, Grad Sch Publ Hlth, Dept Epidemiol, Pittsburgh, PA USA
[6] DYouville Univ, Dept Pharm Practice, Sch Pharm, Buffalo, NY USA
[7] Univ Pittsburgh, Dept Psychiat, Sch Med, 3811 OHara St, Pittsburgh, PA 15213 USA
来源
ALZHEIMER DISEASE & ASSOCIATED DISORDERS | 2023年 / 37卷 / 01期
基金
美国国家卫生研究院;
关键词
anticholinergic burden; mild cognitive impairment; dementia; MILD COGNITIVE IMPAIRMENT; MEDICATIONS; ASSOCIATION; MEMORY; SCALE;
D O I
10.1097/WAD.0000000000000538
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Objective: We investigated whether anticholinergic drug use was related to developing mild cognitive impairment (MCI) or dementia in older adults at the population level. Methods: We used an Anticholinergic Rating (ACR) scale, Clinical Dementia Rating, APOE genotype, and number of prescription medications. We examined time to incident MCI and incident dementia in a population-based cohort (n=1959). We assessed whether developing MCI or dementia was associated with (1) any anticholinergic drug use, (2) total ACR score, or (3) number of anticholinergic drugs taken. Results: Taking any anticholinergic drug was significantly associated with higher risk of developing MCI; however, higher ACR score or higher number of anticholinergic drugs, compared with lower, were not associated with greater risk of developing MCI. We found no significant relationship between anticholinergic use and developing dementia. The relationship between anticholinergic use and cognitive outcome was not affected by APOE genotype. Conclusions: Among cognitively normal older adults in a population-based sample, anticholinergic drug use is independently associated with subsequently developing MCI, but not dementia. Thus, anticholinergic drug use may influence risk of MCI that is nonprogressive to dementia and potentially be a modifiable risk factor for MCI.
引用
收藏
页码:20 / 27
页数:8
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